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1.发明授权Carbohydrate perturbations of viruses or viral antigens and utilization for diagnostic, prophylactic and/or therapeutic applications 失效乙型肝炎病毒感染或病毒抗原以及诊断，预防和/或治疗应用的应用
公开(公告)号：EP0229546B1
公开(公告)日：1991-09-11
申请号：EP86402610.9
申请日：1986-11-25
IPC分类号： G01N33/569 , A61K39/42
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/08 , C07K16/12 , C07K16/18 , C12N2710/16722 , Y02A50/386
摘要： Methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, "perturbation" of an oligosaccharide moiety encompasses any modification that (1) alters the chemical or physicial structure of a carbohydrate residue that is naturally present : (2) that removes, wholly or in part, a carbohydrate residue ; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of methods for oligosacchardie "perturbation" are also described.
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2.发明公开Carbohydrate perturbations of viruses or viral antigens and utilization for diagnostic, prophylactic and/or therapeutic applications 失效Karbohydraten的病症在病毒或病毒抗原和使用在诊断，预防和/或治疗应用。
公开(公告)号：EP0229546A1
公开(公告)日：1987-07-22
申请号：EP86402610.9
申请日：1986-11-25
IPC分类号： G01N33/569 , A61K39/42
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K16/08 , C07K16/12 , C07K16/18 , C12N2710/16722 , Y02A50/386
摘要： Methods for diagnosis, prognosis, prophylaxis and therapy of viral infections are described. The methods employ a virus, viral antigen or fragment thereof in which "perturbation" of an oligosaccharide moiety renders the virus, viral antigen or fragment thereof more specifically recognizable or reactive with neutralizing antibody. As described, "perturbation" of an oligosaccharide moiety encompasses any modification that (1) alters the chemical or physicial structure of a carbohydrate residue that is naturally present : (2) that removes, wholly or in part, a carbohydrate residue ; and/or (3) that prevents or alters addition of a carbohydrate residue. A variety of methods for oligosacchardie "perturbation" are also described.
摘要翻译： 用于诊断，预后，预防和病毒感染的治疗方法描述。 该方法使用一个病毒，病毒抗原或其片段，其中寡糖部分的“扰动”呈现病毒，病毒抗原或其片段更具体地可识别或与中和抗体的反应性。 如所描述的，寡糖部分的“扰动”涵盖任何修改并未（1）年龄碳水化合物残基的化学或结构physicial确实是天然存在：（2）做了移除了，全部或部分，碳水化合物残基; 和/或（3）做了防止或年龄加入碳水化合物残基。 由此描述了多种用于oligosacchardie“扰动”的方法。
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