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1.发明授权PROCEDE ET DISPOSITIF POUR SEPARER PAR FILTRATION VERTICALE DES PARTICULES BIOLOGIQUES CONTENUES DANS UN LIQUIDE 有权用于分离液体的方法和设备所含的生物粒子用垂直过滤
公开(公告)号：EP1866091B1
公开(公告)日：2015-07-29
申请号：EP06726089.3
申请日：2006-03-14
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , UNIVERSITE RENE DESCARTES (PARIS V)
IPC分类号： B01L3/00 , B01L9/00 , C12M1/18 , G01N33/487
CPC分类号： G01N1/4077 , B01L3/50255 , B01L9/523 , B01L2200/0631 , B01L2400/049 , G01N2001/4088
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2.发明公开PROCEDE ET DISPOSITIF POUR SEPARER PAR FILTRATION VERTICALE DES PARTICULES BIOLOGIQUES CONTENUES DANS UN LIQUIDE 有权用于分离液体的方法和设备所含的生物粒子用垂直过滤
公开(公告)号：EP1866091A2
公开(公告)日：2007-12-19
申请号：EP06726089.3
申请日：2006-03-14
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , UNIVERSITE RENE DESCARTES (PARIS V)
IPC分类号： B01L3/00 , B01L9/00 , C12M1/18 , G01N33/487
CPC分类号： G01N1/4077 , B01L3/50255 , B01L9/523 , B01L2200/0631 , B01L2400/049 , G01N2001/4088
摘要： The invention relates to a method of separating biological particles from the liquid containing same for purification, analysis and optionally diagnostic purposes. The inventive method comprises at least one step involving vertical filtration through a filter having a porosity that is adapted to the type of biological particles to be separated, such that said particles are retained by the filter. The invention is characterised in that: (i) the method involves the use of a filter comprising at least one basic filtration zone, whereby each basic filtration zone has a limited surface area; and (ii) the surface area of each basic filtration zone and the number of basic filtration zones are selected as a function of the type of liquid to be filtered, the type of biological particles to be separated and the volume of liquid to be filtered.
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3.发明授权METHODE DE DIAGNOSTIC PRENATAL SUR CELLULE FOETALE ISOLEE DU SANG MATERNEL 有权产前诊断流程操作，从母体血液中一个孤立的胎儿细胞
公开(公告)号：EP1383926B1
公开(公告)日：2015-05-06
申请号：EP02740785.7
申请日：2002-04-30
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , UNIVERSITE RENE DESCARTES (PARIS V)
CPC分类号： C12Q1/6883 , C12Q1/6879 , C12Q2600/156 , G01N33/689 , G01N2800/36 , G01N2800/368
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4.发明公开METHODE DE DIAGNOSTIC PRENATAL SUR CELLULE FOETALE ISOLEE DU SANG MATERNEL 有权产前诊断流程操作，从母体血液中一个孤立的胎儿细胞
公开(公告)号：EP1383926A2
公开(公告)日：2004-01-28
申请号：EP02740785.7
申请日：2002-04-30
申请人： INSTITUT NATIONAL DE LA SANTE ETDE LA RECHERCHE MEDICALE (INSERM) , ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS , UNIVERSITE RENE DESCARTES (PARIS V)
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/569 , G01N33/543
CPC分类号： C12Q1/6883 , C12Q1/6879 , C12Q2600/156 , G01N33/689 , G01N2800/36 , G01N2800/368
摘要： The invention concerns a novel non-invasive prenatal diagnostic method implemented with a sample of maternal blood. Said method enables prenatal diagnosis on isolated non-apoptotic epithelial foetal cells of maternal blood after they have been enriched by filtration, morphologically or immunologically and genetically analysed. Said method is advantageous in that it is perfectly harmless for the mother and the foetus and provides a highly sensitive and specific diagnosis. It enables early detection of a genetic or chromosomal abnormality of the foetus, of a genetic or infectious (viral, bacterial or parasitic) pathology of the foetus, of accurate genotype, and in particular of the genetic sex of the foetus.
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