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1.发明公开
公开(公告)号：EP4263539A1
公开(公告)日：2023-10-25
申请号：EP21831052.2
申请日：2021-12-16
申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE - INSERM , Ecole Polytechnique , UNIVERSITE DE BORDEAUX , Institut Pasteur , Centre National de la Recherche Scientifique
发明人： CHIARAVALLI, Jeanne , GUILLON, Jean , LAVIGNE, Marc , MUNIER-LEHMANN, Hélène , MERGNY, Jean-Louis , MEYER, Björn , SAVRIMOUTOU, Solène
IPC分类号： C07D471/04 , C07D473/00 , C07D473/40 , C07D487/04 , C07D495/04 , A61P31/12 , A61P33/00 , A61K31/519
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公开(公告)号：EP4175976A1
公开(公告)日：2023-05-10
申请号：EP21735736.7
申请日：2021-07-02
发明人： MEYER, Björn , VIGNUZZI, Marco
IPC分类号： C07K14/435 , C12N9/50 , C12Q1/37
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公开(公告)号：EP4127145A1
公开(公告)日：2023-02-08
申请号：EP21722539.0
申请日：2021-03-26
申请人： INSTITUT PASTEUR
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公开(公告)号：EP3932941A1
公开(公告)日：2022-01-05
申请号：EP20305758.3
申请日：2020-07-03
申请人： INSTITUT PASTEUR
发明人： MEYER, Björn , VIGNUZZI, Marco
IPC分类号： C07K14/435 , C12N9/50 , C12Q1/37
摘要： The invention relates to novel means and processes for the detection of a virus in a biological sample comprising cells infected by the virus. In particular, the invention relates to a fluorescent reporter protein designed as a recombinant inactive form of flipGFP suitable for specific activation by viral components in particular by viral proteins, such as viral protease, wherein the viral component recognizes a cleavage site inserted in the recombinant flipGFP. The fluorescent reporter protein is suitable for use in an in vitro method of detection of virus infection in a biological sample when the virus is related to the viral components activating the inactive form of flipGFP into an active fluorescent flipGFP in a biological sample, especially a sample comprising cells, in particular unaltered cells.
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