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1.发明公开IMMUNOLOGICAL SIGNATURES AND PARAMETERS PREDICTING THERAPEUTIC RESPONSES TO ANTI-TNF THERAPY 审中-公开免疫组织化学免疫组织免疫细胞化学参数
公开(公告)号：EP3150716A1
公开(公告)日：2017-04-05
申请号：EP15306536.2
申请日：2015-09-29
申请人： INSTITUT PASTEUR
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N33/6863 , G01N2333/52 , G01N2800/102
摘要： The invention relates to a method of predicting therapeutic responses to anti-TNF blockers before anti-TNF therapy comprising analyzing immune parameters to selected stimuli in patients before therapy and its use for anti-TNF therapy. The invention relates also to a method of determining a predictive biomarker of response to anti-TNF therapy and to the use of the predictive biomarker obtained by the method.
摘要翻译： 本发明涉及一种在抗TNF治疗之前预测抗TNF阻断剂的治疗反应的方法，包括分析治疗前患者选择的刺激物的免疫参数及其用于抗TNF治疗的方法。 本发明还涉及确定对抗TNF治疗的反应的预测生物标志物的方法以及通过该方法获得的预测性生物标志物的使用。
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2.发明公开
公开(公告)号：EP3356548A1
公开(公告)日：2018-08-08
申请号：EP16775179.1
申请日：2016-09-27
申请人： Institut Pasteur , Assistance Publique - Hôpitaux de Paris , Université Paris Descartes - Paris V
CPC分类号： G01N33/6863 , A61K39/105 , A61K39/145 , A61K2039/521 , A61P19/02 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N2333/52 , G01N2800/102 , G01N2800/52 , G01N2800/56 , G01N2800/60
摘要： The invention relates to a method of predicting therapeutic responses to anti-TNF blockers before anti-TNF therapy comprising analyzing immune parameters to selected stimuli in patients before therapy and its use for anti-TNF therapy. The invention relates also to a method of determining a predictive biomarker of response to anti-TNF therapy and to the use of the predictive biomarker obtained by the method.
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