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1.发明公开PEPTIDES OF IL-2 AND DERIVATIVES THEREOF AND THEIR USE AS THERAPEUTIC AGENTS 有权AS治疗物质的IL-2肽和肽衍生物的用途
公开(公告)号：EP1097173A1
公开(公告)日：2001-05-09
申请号：EP99936898.8
申请日：1999-07-16
申请人： INSTITUT PASTEUR
发明人： THEZE, Jacques , ECKENBERG, Ralph , MOREAU, Jean-Louis , GOLDBERG, Michel , ROSE, Thierry , ALZARI, Pedro , MAZIE, Jean-Claude
CPC分类号： C07K14/55 , A61K38/00 , A61K2039/505 , C07K16/246 , C07K2317/34 , C07K2317/73 , G01N33/6869 , Y02A50/473 , Y10S514/885
摘要： The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of IL-2. The invention also relates to DNA sequences encoding the IL-2 peptides, and to methods of using the IL-2 peptides and derivatives and anti-IL-2 antibodies to modulate or mimic or antagonize the biological activities of IL-2 in vivo and to assay for the presence and activity of the IL-2 receptor.
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2.发明授权
公开(公告)号：EP1097173B1
公开(公告)日：2008-05-21
申请号：EP99936898.8
申请日：1999-07-16
申请人： INSTITUT PASTEUR
发明人： THEZE, Jacques , ECKENBERG, Ralph , MOREAU, Jean-Louis , GOLDBERG, Michel , ROSE, Thierry , ALZARI, Pedro , MAZIE, Jean-Claude
CPC分类号： C07K14/55 , A61K38/00 , A61K2039/505 , C07K16/246 , C07K2317/34 , C07K2317/73 , G01N33/6869 , Y02A50/473 , Y10S514/885
摘要： The invention relates to the use as therapeutic agents of IL-2 peptides and derivatives having biological activity and anti-IL-2 antibodies which mimic or modulate the biological activities of IL-2. The invention also relates to DNA sequences encoding the IL-2 peptides, and to methods of using the IL-2 peptides and derivatives and anti-IL-2 antibodies to modulate or mimic or antagonize the biological activities of IL-2 in vivo and to assay for the presence and activity of the IL-2 receptor.
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