公开(公告)号：EP2044064A1

公开(公告)日：2009-04-08

申请号：EP07803843.7

申请日：2007-07-04

申请人： INSTITUT PASTEUR DE LILLE ,  Centre National de la Recherche Scientifique ,  Université de Lille 2 Droit et Santé ,  INSERM (Institut National de la Santé et de la Recherche Medicale)

发明人： DEPREZ, Benoît ,  WILLAND, Nicolas ,  DIRIE, Bertrand ,  TOTO, Patrick ,  VILLERET, Vincent ,  LOCHT, Camille ,  BAULARD, Alain

IPC分类号： C07D413/14 ,  C07D413/12 ,  C07D413/10 ,  A61K31/4725 ,  A61K31/496

CPC分类号： C07D413/14 ,  C07D409/14 ,  C07D417/14

摘要： The present invention relates to the use of compounds having a potentiating effect on the activity of antibiotics activatable via the EthA enzymatic pathway, for the preparation of a medicament for use in preventing and/or treating mycobacterial infections such as tuberculosis and leprosy, to the pharmaceutical compositions containing them in combination with an antibiotic activatable via the EthA pathway, to compounds having a potentiating effect on the activity of antibiotics activatable via the EthA enzymatic pathway, to the pharmaceutical compositions containing them and to their use as a medicament, in particular a medicament for use in preventing and/or treating mycobacterial infections such as tuberculosis and leprosy.

摘要翻译： 本发明涉及的化合物的用途与对抗生素的活性的增强作用并是经由ETHA酶途径活化，用于预防和/或治疗分枝杆菌感染的药物中的制备：如结核病和麻风病，药物组合物 在抗生素包含它们结合并经由ETHA途径活化的，涉及一种具有对抗生素并是经由ETHA酶途径活化的活性的增强作用，以药物组合物包含它们的化合物和它们作为药物，爱尤其药物用于使用 预防和/或治疗分枝杆菌感染：如结核病和麻风病。