专利检索 ap:("INSTITUT PASTEUR DE TUNIS" OR "INSTITUT PASTEUR") AND inv:"DELLAGI, Koussay,Institut Pasteur de Tunis" 第 1 页

1.

发明公开
GENE ASSOCIE A LA VIRULENCE DU PARASITE LEISHMANIA 有权
标题翻译： GEN与毒力相关的利什曼原虫IS

公开(公告)号：EP1414967A2

公开(公告)日：2004-05-06

申请号：EP02751257.3

申请日：2002-06-17

申请人： INSTITUT PASTEUR DE TUNIS , INSTITUT PASTEUR

发明人： BEN ACHOUR, Yosser , CHENIK, Mehdi , LOUZIR, Hechmi , DELLAGI, Koussay,Institut Pasteur de Tunis

IPC分类号： C12N15/30 , C12N9/90 , C07K14/44 , G01N33/50 , G01N33/569 , G01N33/573 , C07K16/40 , C07K16/20 , C12Q1/68

CPC分类号： C12N9/90 , A61K2039/523 , A61K2039/57 , C07K2319/00 , Y02A50/41

摘要： The invention relates to the field of combating leishmaniases. Said invention results from the isolation, from wild isolates of Leishmania major, of a protein-coding gene known as LmPDI which has two regions that are identical to the sequence (Cys-Gly-His-Cys) of the potential active site of the protein disulphide isomerases (PDI). The LmPDI protein is predominantly expressed in the most virulent isolates of the parasite. Said protein forms a novel therapeutic target for developing anti-leishmaniasis medicaments and a novel element that can be used in the composition of immunogenic, and possibly vaccinating, preparations which are intended to protect a human or animal host against Leishmania.