公开(公告)号：EP3087058B1

公开(公告)日：2017-09-06

申请号：EP14830723.4

申请日：2014-12-23

申请人： ISAGRO S.p.A.

发明人： MEAZZA, Giovanni ,  SILLANI, Laura ,  MEREGHETTI, Pierangelo ,  FORGIA, Daniele

IPC分类号： C07C243/28 ,  C07D231/14

CPC分类号： C07D231/14 ,  C07C243/28

摘要： A process is described for the synthesis of pyrazoles having general formula (I) which comprises the steps of mixing a compound having general formula (II) and a 1,2-disubstituted hydrazine having general formula (III) to form a reaction intermediate having general formula (IV) and the reaction mixture obtained in step i), in an acid environment, cyclizes to form a pyrazole having general formula (I), according to reaction scheme 1 Scheme 1.

摘要翻译： 描述了合成具有通式（I）的吡唑的方法，该方法包括将具有通式（II）的化合物和具有通式（III）的1,2-二取代的肼混合以形成具有通式 根据反应方案1方案1，在酸性环境中将式（IV）和步骤i）中获得的反应混合物环化以形成具有通式（I）的吡唑。

公开(公告)号：EP3087058A1

公开(公告)日：2016-11-02

申请号：EP14830723.4

申请日：2014-12-23

申请人： ISAGRO S.p.A.

发明人： MEAZZA, Giovanni ,  SILLANI, Laura ,  MEREGHETTI, Pierangelo ,  FORGIA, Daniele

IPC分类号： C07D231/14

CPC分类号： C07D231/14 ,  C07C243/28

摘要： A process is described for the synthesis of pyrazoles having general formula (I) which comprises the steps of mixing a compound having general formula (II) and a 1,2-disubstituted hydrazine having general formula (III) to form a reaction intermediate having general formula (IV) and the reaction mixture obtained in step i), in an acid environment, cyclizes to form a pyrazole having general formula (I), according to reaction scheme 1 Scheme 1.

摘要翻译： 描述了用于合成具有通式（I）的吡唑的方法，其包括将具有通式（II）的化合物和具有通式（III）的1,2-二取代肼混合以形成具有通式 式（Ⅳ）和在步骤i）中得到的反应混合物在酸性环境中，根据反应方案1方案1，环化形成具有通式（I）的吡唑。