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1.发明授权Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine 失效一种生产2-甲基螺（1,3-氧硫杂环戊烷-5,3“）奎宁环过程
公开(公告)号：EP0683168B1
公开(公告)日：2001-09-12
申请号：EP95107738.7
申请日：1995-05-19
发明人： Hayashi, Koji , Tokumoto, Sho , Yoshizawa, Hiroshi , Isogai, Tatsuo , Kimura, Masaru, Ishihara Sangyo Kaisha Ltd. , Sawaki, Masahiko, Ishihara Sangyo Kaisha Ltd., , Ando, Takayoshi, Ishihara Sangyo Kaisha Ltd., , Katsuyama, Isamu, 346-2, Minamishimohara-cho, , Ariyoshi, Hayato, Ishihara Sangyo Kaisha Ltd., , Nakamura, Tadashi, Ishihara Sangyo Kaisha Ltd.,
IPC分类号： C07D497/20 , A61K31/435
CPC分类号： C07D497/20
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2.发明公开Method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine 失效Verfahren zur Herstellung 2-甲基螺（1,3-氧硫杂环戊烷-5,3'）chinuclidin。
公开(公告)号：EP0683168A1
公开(公告)日：1995-11-22
申请号：EP95107738.7
申请日：1995-05-19
发明人： Hayashi, Koji , Tokumoto, Sho , Yoshizawa, Hiroshi , Isogai, Tatsuo , Kimura, Masaru, Ishihara Sangyo Kaisha Ltd. , Sawaki, Masahiko, Ishihara Sangyo Kaisha Ltd., , Ando, Takayoshi, Ishihara Sangyo Kaisha Ltd., , Katsuyama, Isamu, 346-2, Minamishimohara-cho, , Ariyoshi, Hayato, Ishihara Sangyo Kaisha Ltd., , Nakamura, Tadashi, Ishihara Sangyo Kaisha Ltd.,
IPC分类号： C07D497/20 , A61K31/435
CPC分类号： C07D497/20
摘要： A method for producing 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine, which comprises reacting 3-hydroxy-3-mercaptomethylquinuclidine or a salt thereof and a carbonyl compound in the presence of a catalyst made of at least one member selected from the group consisting of tin halides, oxyacids of phosphorus, phosphorus oxyhalides and organic sulfonic acids, to produce cis-form 2-methylspiro(1,3-oxathiolane-5,3')quinuclidine or a salt thereof.
摘要翻译： 一种2-甲基螺（1,3-氧硫杂环戊烷-5,3'）奎宁环的制备方法，该方法包括使3-羟基-3-巯基乙基奎宁环或其盐与羰基化合物在至少一种 选自锡卤化物，磷酸的氧酸，卤氧化磷和有机磺酸的组分，以制备顺式2-甲基螺（1,3-氧硫杂环戊烷-5,3'）奎宁环或其盐。
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