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    Method for producing pyrimidine compound
    4.
    发明公开
    Method for producing pyrimidine compound 有权
    Verfahren zur Herstellung einer Pyrimidinverbindung

    公开(公告)号：EP2450353A1

    公开(公告)日：2012-05-09

    申请号：EP12000829.7

    申请日：2009-04-16

    申请人： ISHIHARA SANGYO KAISHA, LTD.

    发明人： Murai, Shigeo ,  Koto, Ryoji ,  Yoshizawa, Hiroshi ,  Ohshima, Takeshi ,  Murakami, Katsuyoshi ,  Awazu, Takao ,  Jonishi, Hisayoshi ,  Ando, Takayoshi ,  Nakamura, Tadashi ,  Adachi, Norio ,  Isogai, Akihiko

    IPC分类号： C07D239/42 ,  C07D239/52 ,  C07D401/12

    CPC分类号： C07D239/42 ,  C07D239/52 ,  C07D401/12

    摘要： A method which comprises reacting the compound of the formula (VI):

    (wherein Y is alkyl, arylalkyl or halogen, and p is an integer of from 0 to 3, and each of R 1 and R 2 is methyl, methoxy or ethoxy), with a compound represented by the formula (VII):

    (wherein R 3 is -CF 3 or -CON(R 5 )R 6 , R 4 is inter alia halogen, alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, haloalkylthio, alkoxyalkyl, haloalkoxyalkyl or -N(R 7 )R 8 , each of R 5 and R 6 is a hydrogen atom, alkyl, haloalkyl, alkenyl, alkynyl, alkoxy, haloalkoxy, alkoxyalkyl, haloalkoxyalkyl, cycloalkyl, halocycloalkyl, alkoxycarbonyl, haloalkoxy-carbonyl, phenyl or halophenyl, provided that when either R 5 or R 6 is a hydrogen atom, the other is other than a hydrogen atom, R 5 and R 6 may form a heterocyclic ring together with the adjacent nitrogen atom, each of R 7 and R 8 is a hydrogen atom or alkyl, n is an integer of from 0 to 2, and m is 0 or 1), to produce a compound represented by the formula (VIII):

    摘要翻译： 一种方法，其包括使式（VI）化合物：其中Y是烷基，芳烷基或卤素，p是0-3的整数，R 1和R 2各自是甲基，甲氧基或乙氧基） 与式（VII）表示的化合物反应：（其中R 3为-CF 3或-CON（R 5）R 6，R 4为卤素，烷基，卤代烷基，烷氧基，卤代烷氧基，烷硫基，卤代烷硫基，烷氧基烷基 ，卤代烷氧基烷基或-N（R 7）R 8，R 5和R 6各自为氢原子，烷基，卤代烷基，烯基，炔基，烷氧基，卤代烷氧基，烷氧基烷基，卤代烷氧基烷基，环烷基，卤代环烷基，烷氧羰基，卤代烷氧羰基， 苯基或卤代苯基，条件是当R 5或R 6是氢原子时，另一个不是氢原子，R 5和R 6可以与相邻的氮原子一起形成杂环，R 7和R 8为氢原子或烷基，n为0〜2的整数，m为0或1），得到式（VIII）表示的化合物：