公开(公告)号：EP0672193A1

公开(公告)日：1995-09-20

申请号：EP93922788.0

申请日：1993-09-29

申请人： ISIS PHARMACEUTICALS, INC.

发明人： HANECAK, Ronnie, C. ,  ANDERSON, Kevin, P. ,  BENNETT, C., Frank ,  CHIANG, Ming-Yi ,  BROWN-DRIVER, Vickie, L. ,  ECKER, David, J. ,  VICKERS, Timothy, A. ,  WYATT, Jacqueline, R. ,  IMBACH, Jean, Louis Impasse des Lucques

IPC分类号： C12N15 ,  A01N63 ,  A61K31 ,  A61P31 ,  A61P35 ,  C07H21 ,  C12P19 ,  C12Q1 ,  A61K38

CPC分类号： A61K31/70 ,  A61K38/00 ,  C07H21/00 ,  C12N15/1133 ,  C12N15/1137 ,  C12N15/115 ,  C12N15/117 ,  C12N2310/151 ,  C12N2310/18 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/346 ,  C12Q1/701 ,  C12Y207/07049 ,  C12Y301/01004 ,  C12N2310/3521

摘要： Modified oligonucleotides having a conserved G4 sequence and a sufficient number of flanking nucleotides to significantly inhibit the activity of a virus such as HSV-1 or phospholipase A2 or to modulate the telomere length of a chromosome are provided. G4 quartet oligonucleotide structures are also provided. Methods of prophylaxis, diagnostics and therapeutics for viral-associated diseases and diseases associated with elevated levels of phospholipase A2 are also provided. Methods of modulating telomere length of a chromosome are also provided; modulation of telomere length is believed to play a role in the aging process of a cell and in control of malignant cell growth.