公开(公告)号：EP4403088A1

公开(公告)日：2024-07-24

申请号：EP22870361.7

申请日：2022-09-16

申请人： IUCF-HYU (INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY)

发明人： JANG, Gun Hee ,  LEE, Dae Hee ,  KIM, Seung Uk ,  PARK, Sung Ho

IPC分类号： A61B1/00 ,  A61B1/04 ,  A61B34/00

CPC分类号： A61B34/00 ,  A61B1/00 ,  A61B1/04

摘要： A magnetic field generation module is disclosed. The magnetic field generation module comprises: a main core; at least one auxiliary core located adjacent to the main core; and an auxiliary core driver which moves the auxiliary core along the circumference of the main core by using the center axis of the main core as a shaft.

公开(公告)号：EP4215607A1

公开(公告)日：2023-07-26

申请号：EP21869773.8

申请日：2021-09-17

申请人： IUCF-HYU (Industry-University Cooperation Foundation Hanyang University)

发明人： RYU, Seong Eon ,  JANG, Hye Hyeon ,  KIM, Myeong Bin ,  PARK, Sung Ho

IPC分类号： C12N9/16 ,  A61K38/43 ,  A61P35/00 ,  A61K38/00

摘要： The present invention relates to a tyrosine phosphatase sigma (PTPsigma)-Fc fusion protein comprising a PTPsigma-derived protein and an immunoglobulin (Ig)-derived Fc domain, which can inhibit the signal transduction of PTPsigma by blocking the interaction of the extracellular domain of PTPsigma with a ligand. The PTPsigma-Fc fusion protein of the present invention inhibits PTPsigma-mediated signaling and as such, can promote the growth of blood stem cells, and can be used for preventing or treating PTPsigma-mediated diseases.
Controlling the signal transduction of PTPsigma by utilizing interaction between proteins, the PTPsigma-Fc fusion protein according to the present invention can overcome the problems of conventional inhibitors targeting the active site of PTP. In addition, the solubility of the fusion protein in an aqueous solution can be improved by introducing a mutation thereinto, which makes it possible to apply a high dose to the treatment of the human body and animals.