公开(公告)号：EP0923543B1

公开(公告)日：2003-09-24

申请号：EP97934996.6

申请日：1997-07-23

申请人： Icagen, Inc. ,  ELI LILLY AND COMPANY

发明人： CASTLE, Neil, Alexander ,  HOLLINSHEAD, Sean, Patrick ,  HUGHES, Philip, Floyd ,  MENDOZA, Jose, Serafin ,  WILSON, Joseph, Wendell ,  AMATO, George ,  BEAUDOIN, Serge ,  GROSS, Michael ,  McNAUGHTON-SMITH, Grant

IPC分类号： C07C311/20 ,  C07D213/81 ,  C07C335/20 ,  C07C335/22 ,  C07D261/18 ,  C07C311/29 ,  C07C311/13 ,  C07C311/07 ,  C07C311/21 ,  A61K31/18

CPC分类号： C07C311/20 ,  C07C2602/08

摘要： Compounds of general formula (I) wherein R is H, alkyl or is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R is selected from the group consisting of alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R is hydrogen or methyl; R is hydrogen or methyl; X is C=O, C=S, or SO2; X is C=O or SO2; Y is O, (CH2)p, CH2O, HC=CH or NH; wherein p is 0, 1 or 2; Y is O, (CH2)q, HC=CH or NH; wherein q is 0 or 1; Z is H, OR or NR R ; wherein R is H, (CH2)m-R ; or C(O)-(CH2)m-R ; m = 1 to 5; R is N(R )2, N(R )3L or CO2R ; wherein each R is independently selected from H or alkyl; and L is a counter ion; R is H or alkyl; R is H, alkyl or CO2R ; wherein R is alkyl; or pharmaceutically acceptable salts or prodrugs thereof are useful as potassium channel inhibitors and useful for the treatment of cardiac arrhythmias and cell proliferative disorders.

摘要翻译： 描述了可用作钾通道抑制剂并且特别可用于治疗心律失常和细胞增殖性疾病的化合物。

公开(公告)号：EP0923543A1

公开(公告)日：1999-06-23

申请号：EP97934996.0

申请日：1997-07-23

申请人： Icagen, Inc. ,  ELI LILLY AND COMPANY

发明人： CASTLE, Neil, Alexander ,  HOLLINSHEAD, Sean, Patrick ,  HUGHES, Philip, Floyd ,  MENDOZA, Jose, Serafin ,  WILSON, Joseph, Wendell ,  AMATO, George ,  BEAUDOIN, Serge ,  GROSS, Michael ,  McNAUGHTON-SMITH, Grant

IPC分类号： A61P9 ,  A61K31 ,  A61P43 ,  C07C311 ,  C07C335

CPC分类号： C07C311/20 ,  C07C2602/08

摘要： Compounds of general formula (I) wherein R1 is H, alkyl or is selected from the group consisting of an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R2 is selected from the group consisting of alkyl, an optionally substituted aryl, an optionally substituted heteroaryl, an optionally substituted heterocyclyl and an optionally substituted carbocycloalkyl; R3 is hydrogen or methyl; R4 is hydrogen or methyl; X1 is C=O, C=S, or SO¿2; X?2 is C=O or SO¿2; Y?1 is O, (CH¿2?)p, CH2O, HC=CH or NH; wherein p is 0, 1 or 2; Y?2¿ is O, (CH¿2?)q, HC=CH or NH; wherein q is 0 or 1; Z is H, OR?5 or NR6R7¿; wherein R5 is H, (CH¿2)m-R?8; or C(O)-(CH¿2)m-R?8; m = 1 to 5; R?8 is N(R9)¿2, N(R9)3L or CO2R9; wherein each R9 is independently selected from H or alkyl; and L is a counter ion; R6 is H or alkyl; R7 is H, alkyl or CO¿2R?10; wherein R10 is alkyl; or pharmaceutically acceptable salts or prodrugs thereof are useful as potassium channel inhibitors and useful for the treatment of cardiac arrhythmias and cell proliferative disorders.

公开(公告)号：EP1003495A1

公开(公告)日：2000-05-31

申请号：EP98937136.4

申请日：1998-07-21

申请人： ELI LILLY AND COMPANY

发明人： HOLLINSHEAD, Sean, Patrick ,  HUFF, Bret, Eugene ,  HUGHES, Philip, Floyd ,  MENDOZA, Jose Serafin ,  MITCH, Charles, Howard ,  STASZAK, Michael, Alexander ,  WARD, John, Stanley ,  WILSON, Joseph, Wendell

IPC分类号： A61K31/135 ,  A61K31/155 ,  A61K31/16 ,  A61K31/165 ,  A61K31/18 ,  A61K31/40 ,  A61K31/445 ,  A61K31/535 ,  C07C211/60 ,  C07C233/74 ,  C07C257/18

CPC分类号： C07D213/82 ,  C07C257/12 ,  C07C327/60 ,  C07D295/125 ,  C07D333/38 ,  C07D333/70

摘要： The present invention provides novel indane-like compounds which can be useful for treating psychosis and other conditions associated with the modulation of a muscarinic receptor. The invention provides formulations and methods for using the novel compounds.