公开(公告)号：EP2580312B1

公开(公告)日：2016-07-27

申请号：EP11725438.3

申请日：2011-06-14

申请人： Ifast NV

发明人： MERTENS, Pascal ,  DE VOS, Dirk ,  STEENACKERS, Bart

IPC分类号： C12C3/12

CPC分类号： C07C45/66 ,  C07C51/36 ,  C12C3/12 ,  C07C59/90

公开(公告)号：EP2563898A1

公开(公告)日：2013-03-06

申请号：EP11718015.8

申请日：2011-04-28

申请人： Ifast NV

发明人： DE COOMAN,Luc ,  DE VOS, Dirk ,  MERTENS, Pascal ,  STEENACKERS, Bart

IPC分类号： C12C3/12 ,  C12C3/08 ,  C12C3/10

CPC分类号： C12C3/12 ,  C12C3/08 ,  C12C3/10 ,  Y02P20/582

摘要： The invention relates to a process for the production of iso-alpha-acids starting from hop alpha-acids in which an hop alpha-acid containing feed is contacted with a heterogeneous alkaline earth metal based catalyst, that essentially does not dissolve in the alpha-acid containing feed or in the iso-alpha-acid product phase, either in solvent-free conditions or in the presence of water, carbon dioxide, or an organic solvent or a mixture thereof. The resulting mixture is subjected to a temperature of at least 293 K, preferably under an inert atmosphere, for a time sufficient to effect high conversion of the alpha-acid reactant into the iso-alpha-acid product. The molar ratio of alpha-acid to earth alkaline metal (Mg, Ca, Sr, Ba) varies preferably between 0.2 and 20. After the isomerization process, the heterogeneous alkaline earth metal based catalyst can be quantitatively separated from the iso-alpha-acid product phase by liquid-solid separation techniques.

公开(公告)号：EP2563898B1

公开(公告)日：2018-10-03

申请号：EP11718015.8

申请日：2011-04-28

申请人： Ifast NV

发明人： DE COOMAN,Luc ,  DE VOS, Dirk ,  MERTENS, Pascal ,  STEENACKERS, Bart

IPC分类号： C12C3/12 ,  C12C3/08 ,  C12C3/10

CPC分类号： C12C3/12 ,  C12C3/08 ,  C12C3/10 ,  Y02P20/582

摘要： The invention relates to a process for the production of iso-alpha-acids starting from hop alpha-acids in which an hop alpha-acid containing feed is contacted with a heterogeneous alkaline earth metal based catalyst, that essentially does not dissolve in the alpha-acid containing feed or in the iso-alpha-acid product phase, either in solvent-free conditions or in the presence of water, carbon dioxide, or an organic solvent or a mixture thereof. The resulting mixture is subjected to a temperature of at least 293 K, preferably under an inert atmosphere, for a time sufficient to effect high conversion of the alpha-acid reactant into the iso-alpha-acid product. The molar ratio of alpha-acid to earth alkaline metal (Mg, Ca, Sr, Ba) varies preferably between 0.2 and 20. After the isomerization process, the heterogeneous alkaline earth metal based catalyst can be quantitatively separated from the iso-alpha-acid product phase by liquid-solid separation techniques.

公开(公告)号：EP2580312A1

公开(公告)日：2013-04-17

申请号：EP11725438.3

申请日：2011-06-14

申请人： Ifast NV

发明人： MERTENS, Pascal ,  DE VOS, Dirk ,  STEENACKERS, Bart

IPC分类号： C12C3/12

CPC分类号： C07C45/66 ,  C07C51/36 ,  C12C3/12 ,  C07C59/90

摘要： The invention relates to a process for the production of hexahydro-iso-alpha-acids starting from iso-alpha-acids (or tetrahydro-iso-alpha-acids) in which iso-alpha-acids (or tetrahydro- iso-alpha-acids) are mixed with a heterogeneous ruthenium containing catalyst, that catalyzes the hydrogenation from iso-alpha-acids or tetrahydro-iso-alpha-acids to hexahydro- iso-alpha-acids, either in solvent-free conditions, or in the presence of a solvent phase (e.g. carbon dioxide, water, ethanol or another organic solvent, or mixtures thereof), and in the absence or presence of other hop compounds (such as beta-acids). The resulting mixture is then subjected to a temperature at which the iso-alpha-acid (or tetrahydro-iso-alpha-acid) containing reaction medium is sufficiently low in viscosity to allow easy mixing with the heterogeneous ruthenium containing catalyst and held under a hydrogen containing atmosphere (either pure hydrogen gas or mixed with an inert gas) for a reaction time sufficient to effect high conversion of the iso-alpha-acid (or tetrahydro-iso-alpha-acid) reactant into the hexahydro-iso-alpha-acid product. The molar ratio of iso-alpha-acid or tetrahydro-iso-alpha-acid to ruthenium varies between 1:1 and 2000:1. After the hydrogenation process, the heterogeneous ruthenium containing catalyst can be separated from the hexahydro-iso-alpha-acid product phase by centrifugation, filtration, decantation or other liquid-solid separation techniques. The hydrogenation process can be performed batch-wise or alternatively in continuous mode.