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公开(公告)号：EP1629275A2
公开(公告)日：2006-03-01
申请号：EP04735707.4
申请日：2004-06-02
发明人： LOIBNER, Hans , HIMMLER, Gottfried , JUNGBAUER, Alois , WASSERBAUER, Erich , SCHUSTER, Manfred , HAHN, Rainer , DÜRAUER, Astrid
CPC分类号： C07K16/3076 , A61K2039/505 , C07K14/4748
摘要： The invention relates to a method for the selection of epitopes for immunotherapy, peptides obtained by said method, the use of said peptides as vaccines and diagnostics and an immune serum obtainable by said method.
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2.发明公开
公开(公告)号：EP1370289A2
公开(公告)日：2003-12-17
申请号：EP02706509.3
申请日：2002-03-20
发明人： HIMMLER, Gottfried , LOIBNER, Hans , ECKERT, Helmut , DOBLHOFF-DIER, Otto , KIRCHEIS, Ralf , SCHUSTER, Manfred , WASSERBAUER, Erich , WAXENECKER, Günter
IPC分类号： A61K39/395 , A61K39/39 , A61P37/00
CPC分类号： C07K16/065 , A61K2039/505 , C07K16/06 , C07K16/42
摘要： The invention relates to a method for producing a vaccine, which contains autologous antibodies, characterized by the following steps: preparing a liquid that contains antibodies from a body fluid containing autologous antibodies or from autologous cell preparations or tissue preparations; treating the liquid that contains antibodies with a solid support, on which ligands are immobilized that bond to a defined group of antibodies, with the stipulation that the ligands used are not antibodies or fragments thereof with the same idiotype, directed against tumor-associated antigens; obtaining the antibodies that bond to the ligands, and; processing the obtained antibodies to form an autologous vaccine, which contains an efficient amount of antibodies ranging from several micrograms to one gram.
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公开(公告)号：EP1765871A1
公开(公告)日：2007-03-28
申请号：EP04741000.6
申请日：2004-07-14
发明人： SCHUSTER, Manfred , HIMMLER, Gottfried , WAXENECKER, Günter , MUDDE, Geert, C. , LOIDL, Manuela , REDL, Gerda , LOIBNER, Hans
IPC分类号： C07K16/30 , A61K39/395
CPC分类号： C07K16/34 , C07K16/30 , C07K2317/41 , C07K2317/52 , C07K2317/732 , C07K2317/734
摘要： The invention relates to a monoclonal antibody or derivative or fragment thereof that is derived from a parental monoclonal antibody, that recognizes the Lewis Y antigen, characterized in that the Fc region or region equivalent to the Fc region of said antibody or derivative or fragment thereof carries a bi-sected hybrid type N-glycosylation pattern and that said antibody shows at least 10 fold increased ADCC and at least 10 % reduced CDC activity.
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公开(公告)号：EP1613349A2
公开(公告)日：2006-01-11
申请号：EP04727885.8
申请日：2004-04-16
IPC分类号： A61K39/395 , C07K16/42 , C12N15/63
CPC分类号： C07K16/42 , A61K2039/505 , C07K2317/52 , C07K2319/00
摘要： The invention refers to an immunogenic recombinant antibody designed for immunization of primates comprising at least a part of a murine IgG2a subtype amino acid sequence and a mammalian glycosylation.
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公开(公告)号：EP1503799A2
公开(公告)日：2005-02-09
申请号：EP03726990.9
申请日：2003-05-15
发明人： LOIBNER, Hans , WAXENECKER, Günter , HIMMLER, Gottfried , ECKERT, Helmut , SCHUSTER, Manfred , KIRCHEIS, Ralf
IPC分类号： A61K47/48
CPC分类号： A61K39/0011 , A61K47/68 , A61K2039/6056 , C07K16/30 , C07K16/4266
摘要： The invention relates to an immunogenic antibody which comprises at least two different epitopes of a tumor-associated antigen.
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