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公开(公告)号:EP1320536A1
公开(公告)日:2003-06-25
申请号:EP01975470.4
申请日:2001-09-25
发明人: PHAN, Hieu, Trung , NGUYEN, Lân, Mong , DIEP, Vinh, Van , AZOULAY, Raymond , ESCHENHOF, Harald , NIESOR, Eric, Joseph , BENTZEN, Craig, Leigh , IFE, Robert, John
IPC分类号: C07F9/547 , C07F9/58 , C07F9/6503 , C07F9/6509 , C07F9/6512 , C07F9/6527 , C07F9/6536 , A61K31/675
CPC分类号: A61K31/662 , A61K31/675 , C07F9/588 , C07F9/598 , C07F9/650941 , C07F9/650988 , C07F9/65127 , C07F9/6539 , C07F9/6541
摘要: The present invention relates to novel α-substituted-β-aminoethylphosphonate and α-substituted-β-aminovinylphosphonate derivatives and their uses for lowering plasma levels of apo (a), Lp(a), apo B, apo B associated lipoproteins (low density lipoproteins and very low density lipoproteins) and for lowering plasma levels of total cholesterol.