公开(公告)号：EP2365001A2

公开(公告)日：2011-09-14

申请号：EP10177137.6

申请日：2004-05-03

申请人： Imclone LLC

发明人： Ludwig, Dale L

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/2896 ,  A61K39/39541 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/77 ,  A61K2300/00

摘要： This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific antibodies, or fusion proteins), and to uses of the antibodies and derivatives in therapeutic, and diagnostic methods. The invention relates to nucleic acids encoding the anti-IGF-IR, methods of generating the antibodies and expression. The invention further relates to combination therapies using ant-IGF-IR antibodies with antineoplastic drugs.

摘要翻译： 本发明涉及人抗体也结合人胰岛素样生长因子-1受体（IGF-IR），以论文抗体（Fab的，单链抗体，双特异性抗体，或融合蛋白）的衍生物，和用途 的抗体和衍生物在治疗和诊断方法。 本发明涉及的核酸编码抗IGF-IR，产生抗体和表达的方法。 本发明进一步涉及使用蚂蚁-IGF-IR抗体与抗肿瘤药物的联合疗法。

公开(公告)号：EP2365001A3

公开(公告)日：2012-03-28

申请号：EP10177137.6

申请日：2004-05-03

申请人： Imclone LLC

发明人： Ludwig, Dale L

IPC分类号： C07K16/28 ,  A61K39/395 ,  A61P35/00 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10

CPC分类号： C07K16/2896 ,  A61K39/39541 ,  A61K2039/505 ,  C07K16/2863 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/77 ,  A61K2300/00

摘要： This invention relates to human antibodies that bind to human insulin-like growth factor-1 receptor (IGF-IR), to derivatives of these antibodies (Fabs, single chain antibodies, bi-specific antibodies, or fusion proteins), and to uses of the antibodies and derivatives in therapeutic, and diagnostic methods. The invention relates to nucleic acids encoding the anti-IGF-IR, methods of generating the antibodies and expression. The invention further relates to combination therapies using ant-IGF-IR antibodies with antineoplastic drugs.