-
1.
公开(公告)号:EP3066115A2
公开(公告)日:2016-09-14
申请号:EP14792834.5
申请日:2014-11-03
发明人: WEINSCHENK, Toni , FRITSCHE, Jens , WALTER, Steffen , HILF, Norbert , SCHORR, Oliver , SINGH, Harpreet , KUTTRUFF-COQUI, Sabrina , SONG, Colette
CPC分类号: A61K39/0011 , A61K35/17 , A61K38/1764 , A61K2039/5158 , A61K2039/572 , C07K7/06 , C07K7/08 , C07K14/4748 , C07K14/705 , C07K14/70539 , C07K16/2833 , C07K2319/33 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16
摘要: The present invention relates to peptides, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated cytotoxic T cell (CTL) peptide epitopes, alone or in combination with other tumor-associated peptides that serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses. The present invention relates to peptide sequences and their variants derived from HLA class I and class II molecules of human tumor cells that can be used in vaccine compositions for eliciting anti-tumor immune responses.
摘要翻译: 本发明涉及用于免疫治疗方法的肽,核酸和细胞。 特别地,本发明涉及癌症的免疫治疗。 本发明还涉及肿瘤相关的细胞毒性T细胞(CTL)肽表位,其单独或与作为刺激抗肿瘤免疫应答的疫苗组合物的活性药物成分的其它肿瘤相关肽的组合。 本发明涉及可用于引发抗肿瘤免疫应答的疫苗组合物中的HLA I类和II类分子的肽序列及其变体。