公开(公告)号：EP3380492A1

公开(公告)日：2018-10-03

申请号：EP16805203.3

申请日：2016-11-23

申请人： Immunocore Limited ,  Adaptimmune Limited

发明人： POWLESLAND, Alex ,  PENTIER, Johanne ,  GILGUNN, Sarach ,  GALFRE, Elena

IPC分类号： C07K7/06 ,  C07K14/47

CPC分类号： C07K14/4702 ,  A61K38/00 ,  C07K7/06 ,  C07K14/4748 ,  C07K14/7051 ,  C07K14/70539 ,  C07K16/18 ,  C07K2319/00 ,  G01N33/6872 ,  G01N2333/4703 ,  G01N2333/7051 ,  G01N2333/70539

摘要： The present invention relates to novel peptides derived from Calcium homeostasis modulator protein 3 (CALHM3), complexes comprising such peptides bound to recombinant MHC molecules, and cells presenting said peptide in complex with MHC molecules. Also provided by the present invention are binding moieties that bind to the peptides and/or complexes of the invention. Such moieties are useful for the development of immunotherapeutic reagents for the treatment of diseases such as cancer.