公开(公告)号：EP3365017A1

公开(公告)日：2018-08-29

申请号：EP16858126.2

申请日：2016-10-19

申请人： Immunolight, LLC ,  Duke University

发明人： FATHI, Zakaryae ,  BAYER, Wayne, F. ,  WALDER, Harold ,  BOURKE, Frederic, A. ,  OLDHAM, Mark ,  DEWHIRST, Mark ,  SPECTOR, Neil, L. ,  YOON, Paul ,  ADAMSON, Justus ,  ALCORTA, David ,  LYERLY, Kim ,  LIU, Leihua ,  OSADA, Takuya

IPC分类号： A61K41/00

CPC分类号： A61K41/0057 ,  A61K33/42 ,  A61K41/0066 ,  A61N5/00 ,  A61N5/062 ,  A61N5/10 ,  A61N2005/1098

摘要： A system for treating a diseased site in a human or animal body. The system includes a pharmaceutical carrier including one or more phosphors which are capable of emitting light into the diseased site upon interaction, a photoactivatable drug for intercalating into DNA of cells at the diseased site, one or more devices which infuse the diseased sited with the photoactivatable drug and the pharmaceutical carrier, an x-ray or high energy electron source, and a processor programmed to control a dose of x-rays or electrons to the diseased site for production of light inside the tumor to activate the photoactivatable drug.