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公开(公告)号：EP2976083A2
公开(公告)日：2016-01-27
申请号：EP14767362.8
申请日：2014-03-20
IPC分类号： A61K31/505
CPC分类号： G01N33/56983 , A61K49/0017 , C09B11/08 , C09B11/24 , C09B23/02 , C09B57/00 , C09B57/02 , C09B57/10 , C12Q1/18 , G01N2333/02 , G01N2500/02 , G01N2500/04 , G01N2500/10
摘要： Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.
摘要翻译： 描述了基于杂芳基二氢嘧啶（HAP）的荧光染料（化合物），以及这种染色剂作为诊断试剂，病毒跟踪剂和/或用于药物发现的工具的用途。
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公开(公告)号：EP3057592B1
公开(公告)日：2019-05-22
申请号：EP14853713.7
申请日：2014-10-16
IPC分类号： A61K31/535 , A61K31/497 , C07D413/00
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公开(公告)号：EP3057592A1
公开(公告)日：2016-08-24
申请号：EP14853713.7
申请日：2014-10-16
IPC分类号： A61K31/535 , A61K31/497 , C07D413/00
CPC分类号： A61K31/506 , C07D239/47 , C07D239/48
摘要： Novel assembly effector compounds having a therapeutic effect against hepatitis B viral (HBV) infection are disclosed. Assembly effector molecules described herein can lead to defective viral assembly and also may affect other viral activities associated with chronic HBV infection. Also disclosed is a process to synthesize disclosed compounds, method of treatment of HBV by administration of disclosed compounds, and use of these compounds in the manufacture of medicaments against HBV.
摘要翻译： 公开了具有抗乙型肝炎病毒（HBV）感染的治疗效果的新组装效应物化合物。 本文所述的装配效应分子可导致有缺陷的病毒装配，并且还可能影响与慢性HBV感染相关的其他病毒活性。 还公开了合成公开的化合物的方法，通过给予所公开的化合物治疗HBV的方法，以及这些化合物在制备抗HBV药物中的用途。
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