专利检索 ap:("Indiana University Research AND Technology Corporation" OR "F.Hoffmann-La Roche AG") AND inv:"BELLI, Sara" 第 1 页

1.

发明公开
LIPIDATED INCRETIN RECEPTOR LIGAND HUMAN IMMUNOGLOBULIN FC-REGION FUSION POLYPEPTIDES 审中-公开
标题翻译：融合OFF脂化肠降血糖素受体配体和人免疫球蛋白Fc区

公开(公告)号：EP3082847A1

公开(公告)日：2016-10-26

申请号：EP14830920.6

申请日：2014-12-19

申请人： Indiana University Research and Technology Corporation , F.Hoffmann-La Roche AG

发明人： BELLI, Sara , BLEICHER, Konrad , DIMARCHI, Richard D. , HOFFMANN, Eike , KITAS, Eric A. , KONKAR, Anish A.

IPC分类号： A61K38/26 , C07K14/605 , A61K47/48

CPC分类号： A61K38/26 , A61K38/00 , A61K45/06 , A61K47/543 , C07K14/605 , C07K2319/30

摘要： Herein is reported a fusion polypeptide comprising i) one, two, three or four incretin receptor ligand polypeptides, and ii) one human immunoglobulin Fc-region, wherein at least one of the incretin receptor ligand polypeptides comprises an amino acid that is covalently conjugated to a lipid, and wherein each of the one, two, three or four incretin receptor ligand polypeptides is covalently conjugated by a peptide bond to a terminus of the human immunoglobulin Fc-region, whereby to each terminus of the human immunoglobulin Fc-region only a single incretin receptor ligand polypeptide is conjugated.