公开(公告)号：EP3964507A1

公开(公告)日：2022-03-09

申请号：EP21188077.8

申请日：2014-10-03

申请人： Infinity Pharmaceuticals, Inc.

发明人： CASTRO, Alfredo C. ,  JANARDANANNAIR, Somarajannair ,  EVANS, Catherine A. ,  LESCARBEAU, Andre ,  LIU, Tao ,  TREMBLAY, Martin R.

IPC分类号： C07D403/12 ,  C07D401/14 ,  C07D401/12 ,  C07D403/14 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/4725 ,  A61K31/517 ,  A61P35/00

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：EP2637669A2

公开(公告)日：2013-09-18

申请号：EP11840471.4

申请日：2011-11-10

申请人： Infinity Pharmaceuticals, Inc.

发明人： REN, Pingda ,  LIU, Yi ,  LI, Liansheng ,  CHAN, Katrina ,  WILSON, Troy Edward ,  CASTRO, Alfredo C. ,  EVANS, Catherine A. ,  SNYDER, Daniel A.

IPC分类号： A61K31/555

CPC分类号： C07D473/34 ,  C07D401/12 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04 ,  C07D513/04 ,  C07D519/00

摘要： Compounds and pharmaceutical compositions that modulate kinase activity, including PI3 kinase activity, and compounds, pharmaceutical compositions, and methods of treatment of diseases and conditions associated with kinase activity, including PI3 kinase activity, are described herein.

公开(公告)号：EP2073816B1

公开(公告)日：2011-09-14

申请号：EP07870774.2

申请日：2007-10-10

申请人： Infinity Pharmaceuticals, Inc.

发明人： ADAMS, Julian ,  BEHNKE, Mark L. ,  CASTRO, Alfredo C. ,  EVANS, Catherine A. ,  GRENIER, Louis ,  GROGAN, Michael J. ,  LIU, Tao ,  SNYDER, Daniel A. ,  TIBBITTS, Thomas T.

IPC分类号： A61K31/69 ,  A61P29/00

CPC分类号： C07F5/025 ,  A61K31/69 ,  C07F5/05

摘要： The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.

公开(公告)号：EP2073816A2

公开(公告)日：2009-07-01

申请号：EP07870774.2

申请日：2007-10-10

申请人： Infinity Pharmaceuticals, Inc.

发明人： ADAMS, Julian ,  BEHNKE, Mark L. ,  CASTRO, Alfredo C. ,  EVANS, Catherine A. ,  GRENIER, Louis ,  GROGAN, Michael J. ,  LIU, Tao ,  SNYDER, Daniel A. ,  TIBBITTS, Thomas T.

IPC分类号： A61K31/69 ,  A61P29/00

CPC分类号： C07F5/025 ,  A61K31/69 ,  C07F5/05

摘要： The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.