公开(公告)号：EP1817308A2

公开(公告)日：2007-08-15

申请号：EP05791140.6

申请日：2005-08-26

申请人： Infinity Pharmaceuticals, Inc.

发明人： JANARDANANNAIR, Somarajannair ,  ADAMS, Julian ,  TREMBLAY, Martin ,  NEVALAINEN, Marta ,  CASTRO, Alfredo, C. ,  FOLEY, Michael, A. ,  PORTER, James, R.

IPC分类号： C07D407/04 ,  C07D405/04 ,  C07D307/94 ,  A61K31/4355 ,  A61K31/438

CPC分类号： C07D491/04

摘要： The present invention provides a preparation method for analogs of cyclopamine of formula 1 that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.

摘要翻译： 本发明提供了用于式1的环巴胺类似物的制备方法，其可用于抵消刺猬途径的不需要激活的表型效应，例如由刺猬功能获得，Ptc功能丧失或平滑 获得功能突变。 本发明的化合物特别适用于治疗癌症。

公开(公告)号：EP1817308B1

公开(公告)日：2014-10-08

申请号：EP05791140.6

申请日：2005-08-26

申请人： Infinity Pharmaceuticals, Inc.

发明人： JANARDANANNAIR, Somarajannair ,  ADAMS, Julian ,  TREMBLAY, Martin ,  NEVALAINEN, Marta ,  CASTRO, Alfredo, C. ,  FOLEY, Michael, A. ,  PORTER, James, R.

IPC分类号： C07D407/04 ,  C07D405/04 ,  C07D307/94 ,  A61K31/4355 ,  A61K31/438

CPC分类号： C07D491/04

公开(公告)号：EP1768966A1

公开(公告)日：2007-04-04

申请号：EP05762701.0

申请日：2005-06-17

申请人： Infinity Pharmaceuticals, Inc.

发明人： CASTRO, Alfredo, C. ,  DENG, Wei ,  DEPEW, Kristopher, M. ,  FOLEY, Michael, A. ,  FRITZ, Christian, C. ,  GEORGES EVANGELINOS, Asimina, T. ,  GROGAN, Michael, J. ,  HAFEEZ, Nafeeza ,  HOLSON, Edward, B. ,  HOPKINS, Brian, T. ,  KONEY, Nii, O. ,  LIU, Tao ,  MANN, David, A. ,  MARCAURELLE, Lisa, A. ,  SNYDER, Daniel, A. ,  UNDERWOOD, Dennis, J. ,  WYLIE, Andrew, A. ,  YU, Lin-Chen ,  ZHANG, Linping

IPC分类号： C07D261/02 ,  A61K31/42 ,  A61P35/00

CPC分类号： C07D261/02 ,  C07D261/18 ,  C07D413/10 ,  C07D413/12 ,  C07D417/12 ,  C07D498/04

摘要： One aspect of the present invention relates to isoxazoline derivatives that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising an isoxazoline derivative of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.