专利检索 ap:("Inflazyme Pharmaceuticals, Ltd.") AND inv:"RAMACHANDRAN, Kishore" 第 1 页

1.

发明公开
PROCESS FOR THE PRODUCTION OF 6,7-DIHYDROXY STEROID COMPOUNDS BY ALLYLIC OXIDATION OF STEROID-5-ENE COMPOUNDS TO STEROID-5-ENE-7-ONE COMPOUNDS FOLLOWED BY HYDROBORATION AND OXIDATION AND INTERMEDIATES OF THIS PROCESS 审中-公开
标题翻译：用于生产6,7-二羟基类固醇化合物BY烯丙基氧化类固醇-5- EN链接，相关类固醇5-CN-7-ON连接和HYDRO BORA TION氧化等的中间产品的PROCEDURE

公开(公告)号：EP1404700A2

公开(公告)日：2004-04-07

申请号：EP02727121.2

申请日：2002-05-22

申请人： Inflazyme Pharmaceuticals, Ltd.

发明人： BURGOYNE, David, L. , SHEN, Yaping , JI, Gueijun , ZHOU, Yuanlin , RAMACHANDRAN, Kishore , PASCHALIDES, Nicholas, D. , KELLEHER, Eugene, W.

IPC分类号： C07J21/00

CPC分类号： C07J53/00 , C07J1/0011 , C07J21/008 , C07J41/0038 , Y02P20/55

摘要： Steroids containing a cyclohexene moiety are efficiently oxidized to the corresponding α, β-unsaturated ketone using copper iodide and t-butyl hydroperoxide. A steroid compound containing the α, β-unsaturated ketone structure is efficiently converted to the corresponding vicinal diol using a hydroborating reagent followed by oxidative workup, e.g., borane followed by sodium perborate. Benzoyl and substituted benzoyls are superior protecting groups for hydroxyl groups present in the compounds.