专利检索 ap:("Institut Curie" OR "INSERM (Institut National de la Santé et de la Recherche Médicale)" OR "Centre National de la Recherche Scientifique - CNRS") AND inv:"PACE, Luigia" 第 1 页

1.

发明公开
IMMUNE CELLS DEFECTIVE FOR SUV39H1 审中-公开

公开(公告)号：EP3828264A1

公开(公告)日：2021-06-02

申请号：EP20213944.0

申请日：2018-06-20

申请人： Institut Curie , INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique - CNRS

发明人： AMIGORENA, Sebastian , PIAGGIO, Eliane , GOUDOT, Christel , PACE, Luigia , ALMOUZNI, Geneviève

IPC分类号： C12N5/078 , A61P35/02

摘要： The present invention relates to an engineered immune cell defective for Suv39h1. Preferably, said engineered immune cell further comprises a genetically engineered antigen receptor that specifically binds a target antigen. The present invention also relates to a method for obtaining a genetically engineered immune cell comprising a step consisting in inhibiting the expression and/or activity of Suv39h1 in the immune cell; and further optionally comprising a step consisting in introducing in the said immune cell a genetically engineered antigen receptor that specifically binds to a target antigen. The invention also encompasses said engineered immune cell for their use in adoptive therapy, notably for the treatment of cancer.