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1.发明授权UTILISATION DE FUCANES A DES FINS DE GREFFE, D'INGENIERIE ET DE REGENERATION OSSEUSES 有权脱氧半乳聚糖的用于骨移植， - 设计和再生的目的的应用
公开(公告)号：EP1986712B1
公开(公告)日：2015-12-23
申请号：EP07731017.5
申请日：2007-02-21
申请人： Université René Descartes Paris 5 , Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER)
发明人： IGONDJO-TCHEN CHANGOTADE, Sylvie , SENNI, Karim , FOUCAULT-BERTAUD, Alexandrine , KORB, Grégory , BAROUKH, Maya, Brigitte , SAFFAR, Jean-Louis , GODEAU, Gaston-Jacques , SINQUIN, Corinne , COLLIEC-JOUAULT, Sylvia , DURAND, Patrick
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , A61L2430/02 , C12N5/0654 , C12N2533/70 , C08L5/00
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2.发明公开UTILISATION D'UN POLYSACCHARIDE EXCRETE PAR L'ESPECE VIBRIO DLABOLICUS A DES FINS DE REGENERATION ET DE PROTECTION DU PARODONTE 审中-公开多糖使用与弧菌DLABOLICUS-SPEZIE离休，退休是为了再生和保护牙周治疗的
公开(公告)号：EP1959970A1
公开(公告)日：2008-08-27
申请号：EP06841874.8
申请日：2006-12-06
申请人： Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) , Université René Descartes Paris 5
发明人： SENNI, Karim , SINQUIN, Corinne , COLLIEC-JOUAULT, Sylvia , GODEAU, Gaston-Jacques , GUEZENNEC, Jean
IPC分类号： A61K31/715 , A61L27/20 , A61P1/02
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the regeneration and protection of the non-mineralised connective tissue of the periodontium.
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3.发明授权UTILISATION D' UN POLYSACCHARIDE EXCRETE PAR L'ESPECE VIBRIO DIABOLICUS A DES FINS D'INGENIERIE DES TISSUS CONJONCTIFS NON MINERALISES 有权多糖使用与弧菌-DLABOLICUS-SPEZIE退休的是用于制备非矿化相关组织
公开(公告)号：EP1960011B1
公开(公告)日：2016-04-06
申请号：EP06841875.5
申请日：2006-12-06
申请人： Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) , Université René Descartes - Paris 5
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4.发明公开UTILISATION DE FUCANES A DES FINS DE GREFFE, D'INGENIERIE ET DE REGENERATION OSSEUSES 有权脱氧半乳聚糖的用于骨移植， - 设计和再生的目的的应用
公开(公告)号：EP1986712A2
公开(公告)日：2008-11-05
申请号：EP07731017.5
申请日：2007-02-21
申请人： Université René Descartes Paris 5 , Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER)
发明人： IGONDJO-TCHEN CHANGOTADE, Sylvie , SENNI, Karim , FOUCAULT-BERTAUD, Alexandrine , KORB, Grégory , BAROUKH, Maya, Brigitte , SAFFAR, Jean-Louis , GODEAU, Gaston-Jacques , SINQUIN, Corinne , COLLIEC-JOUAULT, Sylvia , DURAND, Patrick
IPC分类号： A61L27/34
CPC分类号： A61L27/34 , A61L2430/02 , C12N5/0654 , C12N2533/70 , C08L5/00
摘要： The present invention relates to the use of fucans with a weight-average molar mass of between 5000 and 100 000 g/mol, for the purposes of bone grafting, engineering and regeneration.
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5.发明公开UTILISATION D' UN POLYSACCHARIDE EXCRETE PAR L'ESPECE VIBRIO DIABOLICUS A DES FINS D'INGENIERIE DES TISSUS CONJONCTIFS NON MINERALISES 有权多糖使用与弧菌-DLABOLICUS-SPEZIE退休的是用于制备非矿化相关组织
公开(公告)号：EP1960011A1
公开(公告)日：2008-08-27
申请号：EP06841875.5
申请日：2006-12-06
申请人： Institut Francais de Recherche pour l'Exploitation de la Mer (IFREMER) , Université René Descartes - Paris 5
发明人： SENNI, Karim , SINQUIN, Corinne , COLLIEC-JOUAULT, Sylvia , GODEAU, Gaston-Jacques , GUEZENNEC, Jean
摘要： The invention relates to the use of a polysaccharide which is excreted by the Vibrio diabolicus species for the engineering of non-mineralised connective tissues, in particular for skin and cartilage engineering.
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6.发明公开DERIVES DEPOLYMERISES SULFATES D'EXOPOLYSACCHARIDES (EPS), PREPARATION ET UTILISATIONS 有权伤口愈合使用硫酸解聚EXOPOLYSACCHARIDDERIVATE
公开(公告)号：EP1765366A2
公开(公告)日：2007-03-28
申请号：EP05775263.6
申请日：2005-06-06
申请人： Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) , Université René Descartes - Paris 5
发明人： SENNI, Karim , GEUNICHE, Farida , YOUSFI, Miriam , FIORETTI, Florence , GODEAU, Gaston-Jacques , COLLIEC-JOUAULT, Sylvia , RATISKOL, Jacqueline , SINQUIN, Corinne , RAGUENES, Gérard , COURTOIS, Anthony , GUEZENNEC, Jean
IPC分类号： A61K31/737 , A61P19/02 , A61P17/02
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 νg /ml.
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7.发明授权UTILISATION DE DERIVES DEPOLYMERISES SULFATES D'EXOPOLYSACCHARIDES (EPS), COMME CICATRISANTS 有权伤口愈合使用硫酸解聚EXOPOLYSACCHARIDDERIVATE
公开(公告)号：EP1765366B1
公开(公告)日：2012-01-11
申请号：EP05775263.6
申请日：2005-06-06
申请人： Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER) , Université René Descartes - Paris 5
发明人： SENNI, Karim , GEUNICHE, Farida , YOUSFI, Miriam , FIORETTI, Florence , GODEAU, Gaston-Jacques , COLLIEC-JOUAULT, Sylvia , RATISKOL, Jacqueline , SINQUIN, Corinne , RAGUENES, Gérard , COURTOIS, Anthony , GUEZENNEC, Jean
IPC分类号： A61K31/737 , A61P19/02 , A61P17/02 , A61L15/28
CPC分类号： A61K35/28 , A61K31/737 , C08B37/006 , C12N5/0662 , C12N5/0663 , C12N5/0664 , C12N5/0665 , C12N5/0666 , C12N5/0667 , C12N5/0668 , C12N5/0676 , C12N2500/72 , C12N2501/10
摘要： The invention relates to certain low-molecular weight sulphated polysaccharide derivatives of marine native exopolysaccharides (EPSs) excreted by mesophilic marine bacteria from a deep hydrothermal environment, wherein said derivatives can be obtained by means of a method which comprises a step of free radical depolymerisation of said native EPSs followed by a step of sulphating the resulting depolymerised derivatives. The present invention further relates to the use of said low-molecular weight sulphated polysaccharide derivatives as a wound-healing agent, particularly for preparing pharmaceutical compositions suitable for treating or preventing diseases of the connective tissues and particularly skin and gum tissues. The figure demonstrates how polysaccharide derivative GY 785 DRS according to the invention can stimulate fibroblast proliferation in latticed or reconstructed connective tissues at a concentration of 10 νg /ml.
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