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1.发明公开BIOCOMPATIBLE COMPOSITIONS AS CARRIERS OR EXCIPIENTS FOR PHARMACEUTICAL AND NUTRACEUTICAL FORMULATIONS AND FOR FOOD PROTECTION 审中-公开生物相容性赋形剂或用于药物或者食物和保护的辅助化合物
公开(公告)号：EP1395246A1
公开(公告)日：2004-03-10
申请号：EP01935866.2
申请日：2001-05-23
CPC分类号： A61K9/0024 , A61K9/1652 , A61K9/1658 , A61K9/205 , A61K9/2063 , A61K9/7007
摘要： This invention refers to biocompatible carbohydrate polymers such as modified polysaccharides (e.g. chitosan, alginate), associated with milk protein (e.g. caseinate and/or whey proteins) designed to carry bioactive agents. The formulations may be used in various delivery systems including beads, tablets, microencapsulating agents and coatings for oral dosage forms, implants for subcutaneous devices and films for topic administration and food protection. These formulations present improved chemical resistance and exert their activity for prolonged time into gastro-intestinal tract (GIT) and blood circulation as well as for preserving food qualities over long period. The association of modified chitosan, modified alginate with milk proteins results in a stabilized structure able to control the release of drugs, bacteria, bacteriocines, enzymes, nutraceutics, etc. into enteric, topic or systemic route.
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