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1.发明公开
公开(公告)号：EP2880059A1
公开(公告)日：2015-06-10
申请号：EP13748004.2
申请日：2013-08-02
申请人： Institut National de la Santé et de la Recherche Médicale (INSERM) , Centre National de la Recherche Scientifique (CNRS) , Université Paris Descartes , Fondation Imagine , Assistance Publique Hôpitaux De Paris , Université Paris Diderot - Paris 7 , Université Paris-Sud XI
CPC分类号： C07K16/2881 , A61K2039/505 , C07K2317/24 , C07K2317/76
摘要： The present disclosure relates to antagonists of transferrin receptor and compositions and methods of use of said antagonists for treating pathological disorders such as thalassemia disorders
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2.发明公开COMPOSITION COMPRISING A COMBINATION OF DNA METHYLATION INHIBITOR AND A VITAMIN D RECEPTOR AGONIST FOR THE TREATMENT OF DRUG RESISTANT CANCER OR FOR THE PREVENTION OF TUMOR RELAPSE 审中-公开有用于癌症药物用于预防肿瘤复发耐于治疗DNA甲基化抑制剂和维生素D受体激动剂的组合组成
公开(公告)号：EP3157533A1
公开(公告)日：2017-04-26
申请号：EP15729204.6
申请日：2015-06-19
申请人： INSERM (Institut National de la Santé et de la Recherche Médicale) , Centre National de la Recherche Scientifique (C.N.R.S.) , Université Paris Descartes , Fondation Imagine , Université Paris Diderot - Paris 7 , Universite Paris-Sud , Assistance Publique-Hôpitaux de Paris (APHP)
发明人： CRUZ-MOURA, Ivan , HERMINE, Olivier , PAUBELLE, Etienne , DUSSIOT, Michaël , TROVATI MACIEL, Thiago , ZYLBERSZTEJN, Florence
IPC分类号： A61K31/593 , A61K31/341 , A61K31/53
CPC分类号： A61K31/706 , A61K31/341 , A61K31/53 , A61K31/593 , A61K45/06 , A61K2300/00
摘要： The present invention concerns a combination of (i) a DNA methylation inhibitor, and (ii) a Vitamin D receptor agonist, for simultaneous or sequential use in the treatment of a drug resistant cancer and/or in prevention of tumor relapse in a patient suffering from cancer. The present invention also relates to a combination of (i) a DNA methylation inhibitor, and (ii) a Vitamin D receptor agonist, for increasing, restoring or enhancing sensitivity of a patient suffering from cancer to a chemotherapeutic drug in a patient suffering from cancer.
摘要翻译： 本发明涉及和/或预防肿瘤复发中的患者用于在耐药性癌症的治疗中同时或依次使用（ⅰ）的DNA甲基化抑制剂，和（ii）维生素D受体激动剂的组合， 从癌症。 因此，本发明涉及式（I）的DNA甲基化抑制剂，和组合（ⅱ）维生素D受体激动剂，在从患有癌症的患者增加，恢复或增强从患有癌症的患者的灵敏度对化疗药物 ，
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