公开(公告)号：EP1860119A1

公开(公告)日：2007-11-28

申请号：EP06714335.4

申请日：2006-02-22

申请人： Institute for Antibodies Co., Ltd. ,  Kurosawa, Yoshikazu

发明人： AKAHORI, Yasushi ,  SUGIOKA, Atsushi, VIEQU COURT DENJIYAMA ,  HAYASHI, Nobuhiro ,  TAKASAKI, Akihiko ,  SUZUKI, Kazuhiro ,  MORITA, Miwa ,  KUROSAWA, Yoshikazu ,  IBA, Yoshitaka ,  SUMITOMO, Mariko ,  TSUTSUMI, Susumu ,  OGAWA, Keiko ,  MATSUDA, Kazuki ,  MURAMATSU, Chiho ,  TAKAHASHI, Nobuhiro, c/ The Faculty of Agriculture ,  FUJIYAMA, Sari, c/o The Faculty of Agriculture ,  AZUMA, Masachika, c/o Inst. Antibodies Co., Ltd ,  UKAI, Yoshinori, c/o Inst. Antibodies Co., Ltd ,  MORISHITA, Kazuhiro, Miyazaki Medical College, Dept. of Biochemistry

IPC分类号： C07K16/28 ,  A61K39/00 ,  A61P35/00 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/02 ,  G01N33/15 ,  G01N33/50

CPC分类号： C07K16/303 ,  A61K2039/505 ,  C07K16/2803 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2319/00 ,  G01N33/57426 ,  G01N33/57438

摘要： It is intended to clarify a molecule which is available as a target in treating or diagnosing cancer and utilize the molecule in the medical field or the research field. By treating IgSF4, which has been identified as a molecule specifically expressen in lung cancer cells, with an antibody, and ADCC activity is exerted. Based on this finding, an anti-IgSF4 antibody is provided as a means efficacious in treatig cancer, etc.

摘要翻译： 旨在澄清可用作治疗或诊断癌症并在医学领域或研究领域中利用分子的靶标的分子。 通过用抗体处理被鉴定为在肺癌细胞中特异性表达的分子的IgSF4，并施加ADCC活性。 基于该发现，提供抗IgSF4抗体作为治疗癌症等方面的有效手段。