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1.发明授权DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS 有权取代的酒石酸衍生物的衍生物和用于制备β分泌酶抑制剂的用途
公开(公告)号：EP2116526B1
公开(公告)日：2018-04-18
申请号：EP07702276.2
申请日：2007-02-05
发明人： LI, Song , LIAO, Guochao , XIAO, Junhai , NIE, Aihua , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing
IPC分类号： C07C235/12 , C07D241/04 , A61K31/16 , A61K31/4965 , A61P25/28 , A61P25/00 , A61P43/00 , C07D235/06
CPC分类号： C07C235/16 , C07C235/12 , C07C237/42 , C07C2601/14 , C07D235/06 , C07D295/185
摘要： The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof: in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of ²-amyloid peptide.
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2.发明公开DERIVATES OF SUBSTITUTED TARTARIC AICD AND USAGE FOR PREPARATING BETA SECRETASE INHIBITORS 有权VERWENDUNG ZUR HERSTELLUNG VON BETA-SEKRETASEHEMMERN中的替代品替代品
公开(公告)号：EP2116526A1
公开(公告)日：2009-11-11
申请号：EP07702276.2
申请日：2007-02-05
发明人： LI, Song , LIAO, Guochao , XIAO, Junhai , NIE, Aihua , WANG, Lili , ZHONG, Wu , ZHENG, Zhibing
IPC分类号： C07C235/12 , C07D241/04 , A61K31/16 , A61K31/4965 , A61P25/28 , A61P25/00 , A61P43/00
CPC分类号： C07C235/16 , C07C235/12 , C07C237/42 , C07C2601/14 , C07D235/06 , C07D295/185
摘要： The present invention relates to compounds represented by formula (I), or isomers, prodrugs, pharmaceutically acceptable salts, solvates or hydrates thereof:
in which each substituent of formula (I) is as defined in the specification. The present invention also relates to preparation methods of compounds represented by formula (I), a pharmaceutical composition comprising compounds represented by formula (I) and usage of compounds represented by formula (I) for treating chronic neurodegenerative diseases such as Alzheimer's disease and other diseases induced by aggregation or deposition of β-amyloid peptide.摘要翻译： 本发明涉及由式（I）表示的化合物或其异构体，前体药物，药学上可接受的盐，溶剂合物或水合物：其中式（I）的每个取代基如说明书中所定义。 本发明还涉及由式（I）表示的化合物的制备方法，包含由式（I）表示的化合物和式（I）表示的化合物用于治疗慢性神经变性疾病如阿尔茨海默病和其他疾病的药物组合物的制备方法 通过β-淀粉状蛋白肽的聚集或沉积诱导。
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