专利检索 ap:("Instituto Biomar S.A.") AND inv:"YOSIEF, Tesfamariam, Pharma Mar S.A." 第 1 页

1.

发明授权
CYTOTOXIC ALKALOID DERIVATIVES INCLUDING ASMARINE A AND B ISOLATED FROM A SPONGE 有权
标题翻译：细胞毒性生物碱衍生物Asmarine A和B EMBRACE，并从海绵ISOLATED WERE

公开(公告)号：EP1070067B1

公开(公告)日：2005-03-02

申请号：EP98962610.6

申请日：1998-12-23

申请人： Instituto Biomar S.A.

发明人： KASHMAN, Yoel, Pharma Mar S.A. , RUDI, Amira, Pharma Mar S.A. , YOSIEF, Tesfamariam, Pharma Mar S.A. , GRAVALOS, Dolores G., Pharma Mar S.A.

IPC分类号： C07D487/06 , A61K31/505

CPC分类号： C07D487/16

摘要： Asmarine A and B, novel cytotoxic diterpene-alkaloids, have been isolated from the sponge Raspailia sp. The structure of these compounds have been established on the basis of NMR data and confirmed by X-ray analysis. Also claimed are compounds (I) or (II), wherein R1 represents hydrogen or lower alkyl or lower alkanoyl; R2 represents hydrogen or lower alkyl; R3 is either an alkyl or a cycloalkyl group containing one or more isopreneunits, or a monoterpene or a sesquiterpene or a sesquiterpene or a diterpene group; R4 or R5 represent hydrogen or lower alkyl; R6 represents lower alkyl; X represents F or Cl or Br or (I).