公开(公告)号：EP2548572A2

公开(公告)日：2013-01-23

申请号：EP11777295.4

申请日：2011-05-05

申请人： Instituto Finlay, Centro de Investigacion-Produccion de vacunas y sueros

发明人： PÉREZ MARTÍN, Oliver Germán ,  PÉREZ CUELLO, Maribel ,  CABRERA BLANCO, Osmir ,  BALBOA GONZÁLEZ, Julio Antonio ,  LASTRE GONZÁLEZ, Miriam de San Juan Bosco ,  ZAYAS VIGNIER, Caridad, Caridad ,  GONZÁLEZ AZNAR, Elizabeth ,  ROMEU ALVAREZ, Belkis

IPC分类号： A61K39/015 ,  A61P33/06

CPC分类号： A61K39/015 ,  A61K2039/55 ,  A61K2039/55555 ,  A61K2039/55594 ,  A61K2039/57 ,  Y02A50/412 ,  Y02A50/484

摘要： The invention relates to the field of vaccinal compositions for the effective or preventive treatment of vertically transmitted infections, especially malaria and preferably human malaria caused by Plasmodium falciparum. The technical aim of the invention is to use the tolerogens transferred, at an early stage, from the mother to the foetus/newborn and to formulate them with potent adjuvants that are inducers of Th1 and cytotoxic T-cell responses in order to use same in prophylactic or therapeutic vaccines against vertically transmitted infections, especially malaria. The use of said formulations at early ages via the parenteral route or via the mucosal route or both at the same time reverts the tolerance induced by the transfer of tolerogens, thereby inducing protective responses.

摘要翻译： 本发明涉及用于有效或预防治疗由恶性疟原虫引起的垂直传播感染，特别是疟疾和优选人类疟疾的疫苗组合物领域。 本发明的技术目的是使用从母体转移到胎儿/新生儿的早期转运的耐受剂，并用作为Th1诱导剂和细胞毒性T细胞应答的有效佐剂来配制它们，以便在 针对垂直传播的感染，特别是疟疾的预防或治疗性疫苗。 通过肠胃外途径或通过粘膜途径或两者同时在早期使用所述制剂来回复由转移耐受性引起的耐受性，从而诱导保护性反应。