公开(公告)号：EP1328306B1

公开(公告)日：2005-11-23

申请号：EP01982122.2

申请日：2001-09-19

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： A61M1/14

CPC分类号： A61K9/0024 ,  A61K9/143

公开(公告)号：EP1331848A1

公开(公告)日：2003-08-06

申请号：EP01982123.0

申请日：2001-09-19

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard ,  HUPE, Gerhard

IPC分类号： A01N25/08 ,  C08K3/34 ,  C08K9/12

CPC分类号： A01N25/08

摘要： The invention relates to a material used for producing products (1) having disinfecting and/or antifungal properties. Said material has at least one matrix (2), in which a molecular sieve is incorporated. Said molecular sieve is loaded with: at least one active substance (Z) having a disinfecting and/or antifungal effect; or at least one first active substance (Z1) having a disinfecting effect and a second active substance (Z2) having an antifungal effect. The corresponding molecular sieve/active substance adduct (3) releases the active substance(s) in conjunction with the aqueous body fluid when the matrix (2) is in contact with a body surface (4) of the human, animal or plant type. The inventive material is characterized in that the molecular sieve/active substance adduct (3) additionally contains water of crystallization to such an extent that the molecular sieve is partially dehydrated with regard to a sufficient basic molar quantity (m) of water of crystallization. The molecular sieve is loaded with the reduced molar quantity (m') of water of crystallization with the active substance(s) (Z, Z1, Z2) so that an adsorption of water with the desorption of the corresponding active substance occurs when the matrix (2) is in contact with the body surface (4), whereby the water of crystallization of the molecular sieve increases. The invention also relates to an advantageous method for producing the inventive active substance.

公开(公告)号：EP1328306A2

公开(公告)日：2003-07-23

申请号：EP01982122.2

申请日：2001-09-19

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： A61M1/14

CPC分类号： A61K9/0024 ,  A61K9/143

摘要： The invention relates to a material for producing products (1) having fibrinolytic and/or antibacterial properties. Said material has at least one matrix (2), which is compatible with body tissue and in which a molecular sieve is incorporated. Said molecular sieve is loaded with: at least one active substance (Z) having a fibrinolytic or antibacterial effect; or at least one first active substance (Z1) having a fibrinolytic effect and a second active substance (Z2) having an antibacterial effect. The corresponding molecular sieve/active substance adduct (3) releases the active substance(s) in conjunction with the aqueous body fluid when the matrix (2) is in contact with the body tissue (4). The inventive material is characterized in that the molecular sieve/active substance adduct (3) additionally contains water of crystallization to such an extent that the molecular sieve is partially dehydrated with regard to a sufficient basic molar quantity (m) of water of crystallization. The molecular sieve is loaded with the reduced molar quantity (m') of water of crystallization with the active substance(s) (Z, Z1, Z2) so that an adsorption of water with the desorption of the corresponding active substance occurs when the matrix (2) is in contact with the body tissue (4), whereby the water of crystallization of the molecular sieve increases. The invention also relates to an advantageous method for producing the inventive active substance.

公开(公告)号：EP1267845A1

公开(公告)日：2003-01-02

申请号：EP01919140.2

申请日：2001-02-23

申请人： Intech Thüringen GmbH

发明人： SCHUNK, Werner ,  BRUDER, Michael ,  GIESSMANN, Konrad ,  KRAUSE, Karl-Heinz ,  MERKMANN, Gerhard

IPC分类号： A61K9/70

CPC分类号： A61K9/7038

摘要： The invention relates to a plaster containing an active agent (1), comprising at least one cover membrane (2) and an active membrane (3) which is based on a skin-compatible matrix (4) containing a molecular sieve which is loaded with at least one active agent (Z, Z1, Z2). The molecular sieve/active agent adduct (5) releases the active agent when the active membrane comes into contact with the skin (6), in conjunction with the transpired water of the skin. The inventive plaster (1) is characterised in that the molecular sieve/active agent adduct (5) also contains water of crystallisation, to the extent that the molecular sieve is partially dehydrated compared to a sufficient basic molar quantity (m) of water of crystallisation, said molecular sieve with the reduced molar quantity (m') of water of crystallisation being loaded with the active agent (Z, Z1, Z2) so that when the active membrane (3) comes into contact with the skin (6), water is adsorbed and the active agent is desorbed, whereupon the water of crystallisation content of the molecular sieve increases. The invention also relates to various suitable embodiments of the plaster (1) containing an active agent and to an advantageous method for producing the inventive plaster (1) containing an active agent (1).