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    RNASE-H-based assays utilizing modified RNA monomers
    2.
    发明公开
    RNASE-H-based assays utilizing modified RNA monomers 有权
    RNASE-H-BASIERTE测定单核苷酸修饰型RNA单体

    公开(公告)号：EP2644708A1

    公开(公告)日：2013-10-02

    申请号：EP13173389.1

    申请日：2009-04-30

    申请人： Integrated Dna Technologies, Inc.

    发明人： Walder, Joseph Alan ,  Behlke, Mark Aaron ,  Rose, Scott ,  Dobosy, Joseph

    IPC分类号： C12Q1/68

    CPC分类号： C12N9/96 ,  C12Q1/6844 ,  C12Q1/6853 ,  C12Q2549/101 ,  C12Q2525/186 ,  C12Q2521/301 ,  C12Q2525/121

    摘要： The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3' end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.

    摘要翻译： 本发明涉及用于各种生物测定的新型寡核苷酸化合物，例如核酸扩增，连接和测序反应。 该寡核苷酸在寡核苷酸的3'末端或其附近包含核糖核酸结构域和封闭基团。 这些化合物提供了前所未见的增加的特异性水平。 还提供了进行核酸扩增，连接和测序的方法。 此外，本文还公开了含有寡核苷酸的试剂盒。

    RNase-H-based assays utilizing modified RNA monomers
    3.
    发明公开
    RNase-H-based assays utilizing modified RNA monomers 有权
    RNase-H basierte测定Verwendung von RNA Monomeren

    公开(公告)号：EP2644707A1

    公开(公告)日：2013-10-02

    申请号：EP13173388.3

    申请日：2009-04-30

    申请人： Integrated Dna Technologies, Inc.

    发明人： Walder, Joseph Alan ,  Behlke, Mark Aaron ,  Rose, Scott ,  Dobosy, Joseph

    IPC分类号： C12Q1/68

    CPC分类号： C12N9/96 ,  C12Q1/6844 ,  C12Q1/6853 ,  C12Q2549/101 ,  C12Q2525/186 ,  C12Q2521/301 ,  C12Q2525/121

    摘要： The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3' end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.

    摘要翻译： 本发明涉及用于各种生物测定的新型寡核苷酸化合物，例如核酸扩增，连接和测序反应。 该寡核苷酸在寡核苷酸的3'末端或其附近包含核糖核酸结构域和封闭基团。 这些化合物提供了前所未见的增加的特异性水平。 还提供了进行核酸扩增，连接和测序的方法。 此外，本文还公开了含有寡核苷酸的试剂盒。

    RNase-H-based assays utilizing modified RNA monomers
    5.
    发明公开
    RNase-H-based assays utilizing modified RNA monomers 有权
    利用修饰的RNA单体的基于RNase-H的测定

    公开(公告)号：EP2644710A1

    公开(公告)日：2013-10-02

    申请号：EP13173391.7

    申请日：2009-04-30

    申请人： Integrated Dna Technologies, Inc.

    发明人： Walder, Joseph Alan ,  Behlke, Mark Aaron ,  Rose, Scott ,  Dobosy, Joseph

    IPC分类号： C12Q1/68

    CPC分类号： C12N9/96 ,  C12Q1/6844 ,  C12Q1/6853 ,  C12Q2549/101 ,  C12Q2525/186 ,  C12Q2521/301 ,  C12Q2525/121

    摘要： The present invention pertains to novel oligonucleotide compounds for use in various biological assays, such as nucleic acid amplification, ligation and sequencing reactions. The novel oligonucleotides comprise a ribonucleic acid domain and a blocking group at or near the 3' end of the oligonucleotide. These compounds offer an added level of specificity previously unseen. Methods for performing nucleic acid amplification, ligation and sequencing are also provided. Additionally, kits containing the oligonucleotides are also disclosed herein.

    摘要翻译： 本发明涉及用于各种生物测定法例如核酸扩增，连接和测序反应的新寡核苷酸化合物。 新寡核苷酸在寡核苷酸的3'末端或其附近包含核糖核酸结构域和封闭基团。 这些化合物提供了先前未见的额外水平的特异性。 还提供了进行核酸扩增，连接和测序的方法。 另外，本文还公开了含有寡核苷酸的试剂盒。