公开(公告)号：EP2207874B1

公开(公告)日：2014-12-03

申请号：EP08836827.9

申请日：2008-10-08

申请人： Intrexon Corporation ,  University of Pittsburgh - Of the Commonwealth System of Higher Education

发明人： BRAUGHLER, J., Mark ,  KUMAR, Prasanna ,  STORKUS, Walter, J. ,  OKADA, Hideho

IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N15/00

CPC分类号： A61K35/15 ,  A61K31/00 ,  A61K31/166 ,  A61K31/4245 ,  A61K38/00 ,  A61K45/06 ,  C07K14/5434 ,  C07K2319/715 ,  C12N5/0639 ,  C12N2501/23 ,  C12N2501/24 ,  C12N2510/00 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2840/203 ,  G01N33/6866 ,  G01N2333/57 ,  G01N2800/52 ,  A61K2300/00

摘要： This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL- 12) under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals including human.

公开(公告)号：EP2207874A1

公开(公告)日：2010-07-21

申请号：EP08836827.9

申请日：2008-10-08

申请人： Intrexon Corporation ,  University of Pittburgh of the Commonwealth System of Higher Education

发明人： BRAUGHLER, J., Mark ,  KUMAR, Prasanna ,  STORKUS, Walter, J. ,  OKADA, Hideho

IPC分类号： C12N5/00 ,  C12N5/02 ,  C12N15/00

CPC分类号： A61K35/15 ,  A61K31/00 ,  A61K31/166 ,  A61K31/4245 ,  A61K38/00 ,  A61K45/06 ,  C07K14/5434 ,  C07K2319/715 ,  C12N5/0639 ,  C12N2501/23 ,  C12N2501/24 ,  C12N2510/00 ,  C12N2710/10343 ,  C12N2830/002 ,  C12N2840/203 ,  G01N33/6866 ,  G01N2333/57 ,  G01N2800/52 ,  A61K2300/00

摘要： This invention provides the field of therapeutics. Most specifically present invention provides methods of generating in vitro engineered dendritic cells conditionally expressing interleukin-12 (IL- 12) under the control of a gene expression modulation system in the presence of activating ligand and uses for therapeutic purposes in animals including human.

摘要翻译： 本发明提供了治疗学领域。 最具体地说，本发明提供了在活化配体存在下在基因表达调节系统的控制下产生条件性表达白细胞介素-12（IL-12）的体外工程树突细胞的方法，以及用于包括人在内的动物的治疗目的。