公开(公告)号：EP2424854A2

公开(公告)日：2012-03-07

申请号：EP10767835.1

申请日：2010-04-23

申请人： Invasc Therapeutic, Inc.

发明人： RAJAGOPAL, Desikan

IPC分类号： C07D317/46 ,  C07D405/02 ,  A61P9/00 ,  A61K31/357

CPC分类号： C07D317/64 ,  A61K31/357 ,  C07D207/16 ,  C07D211/60 ,  C07D217/26 ,  C07D317/66 ,  C07D317/68 ,  C07D317/72 ,  C07D319/18 ,  C07D319/20 ,  C07D405/12

摘要： Ortho methoxy phenolic compounds are provided that include methylenedioxyphenyl ferulate and ferulylproline and derivatives thereof. Pharmaceutical compositions comprising the compounds and methods of using the compounds for treating cardiovascular diseases, including hypertension, atherosclerosis, coronary heart disease, angina, stroke, and myocardial infarction, are further provided. The compounds are also useful in reducing low-density lipoprotein oxidation, improving or increasing vasodilation, and reducing plaque destabilization in a subject.

摘要翻译： 提供的邻位甲氧基酚类化合物包括亚甲基二氧苯基阿魏酸酯和阿魏酸脯氨酸及其衍生物。 进一步提供了包含所述化合物的药物组合物和使用所述化合物治疗心血管疾病（包括高血压，动脉粥样硬化，冠心病，心绞痛，中风和心肌梗塞）的方法。 这些化合物还可用于降低受试者的低密度脂蛋白氧化，改善或增加血管舒张并减少斑块失稳。

公开(公告)号：EP2358707A2

公开(公告)日：2011-08-24

申请号：EP09821336.6

申请日：2009-10-16

申请人： Invasc Therapeutic, Inc.

发明人： RAJAGOPAL, Desikan

IPC分类号： C07D409/12 ,  C07D207/16 ,  C07D207/08 ,  A61K31/4015 ,  A61P9/12 ,  A61P25/28

CPC分类号： A61K31/4015 ,  C07D207/08 ,  C07D207/16 ,  C07D209/52 ,  C07D211/60 ,  C07D217/24 ,  C07D409/12 ,  C07D409/14

摘要： Compounds are provided which can be useful in reducing the activity of an angiotensin-converting enzyme and thus be used to treat or prevent a renin-angiotensin aldosterone system-related disorder. These compounds include lipoic acid derivatives such as prolyl lipoic acid and pipecolinyl lipoic acid, and other compounds, and these compounds are useful in treating hypertension, stroke, or other renin-angiotensin aldosterone system-related disorders in human or animal patients. Pharmaceutical compositions prepared using these compounds and methods of treatment using these compounds are also provided.

公开(公告)号：EP2324005A1

公开(公告)日：2011-05-25

申请号：EP09791197.8

申请日：2009-08-05

申请人： The Ohio State University Research Foundation ,  Invasc Therapeutic, Inc.

发明人： PARTHASARATHY, Sampath ,  RAJAGOPALAN, Sanjay ,  RAJAGOPAL, Desikan

IPC分类号： C07D317/64 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12 ,  A61K31/36 ,  A61K31/385 ,  A61K31/4025 ,  A61K31/4178 ,  A61K31/4709 ,  A61K31/496 ,  A61P3/10 ,  A61P9/00 ,  A61P29/00

CPC分类号： A61K31/385 ,  A61K31/36 ,  A61K45/06 ,  C07D317/64 ,  C07D405/06 ,  C07D405/12 ,  C07D409/12

摘要： The present invention provides novel methylenedioxy phenolic compounds and their derivatives, methods of making them and methods of using them to treat or prevent cardiovascular disease, vascular disease and/or inflammatory disease, as well as Type I and Type II Diabetes and Dyslipidemia patients at risk for hypertension, stroke, cardiovascular and renal disease.