公开(公告)号：EP2640423B1

公开(公告)日：2017-07-26

申请号：EP11793558.5

申请日：2011-11-10

申请人： Ischemix LLC

发明人： BAGUISI, Alexander, B. ,  BEEUWKES, Reinier ,  CASALE, Ralph ,  KATES, Steven, A. ,  LADER, Alan, S.

IPC分类号： A61K47/64 ,  C07K5/06 ,  C07D339/04 ,  C07F9/6553 ,  C07K5/062 ,  C07K5/065 ,  C07K5/072

CPC分类号： C07D339/04 ,  A61K47/64 ,  C07F9/655345 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/06104 ,  C07K5/06113

公开(公告)号：EP4282411A1

公开(公告)日：2023-11-29

申请号：EP23173043.3

申请日：2018-04-25

申请人： Ischemix LLC

发明人： BAGUISI, Alexander ,  BEEUWKES, Reinier ,  CASALE, Ralph ,  DEWAHL, David, A. Jr. ,  KATES, Steven, A. ,  LADER, Alan, S.

IPC分类号： A61K31/385 ,  A61K31/4178 ,  A61K31/661 ,  A61K31/662 ,  A61K45/06 ,  A61K38/06 ,  A61K9/00 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00

摘要： The present invention relates, in certain embodiments, to methods for preventing and/or treating neurodegenerative damage (e.g., secondary cascade of neurodegenerative damage) and improving functional outcomes (e.g., outcomes associated with cognitive, behavior and sensorimotor function) caused by traumatic brain injury using neuroprotective lipoyl compounds. The present invention also provides, in various embodiments, compositions for use in treating and/or preventing TBI in a subject in need thereof, compounds for use in the manufacture of a medicament for treating and/or preventing TBI in a subject in need thereof, and methods of preparing a pharmaceutical composition for treating and/or preventing secondary brain damage caused by TBI.

公开(公告)号：EP3615023A1

公开(公告)日：2020-03-04

申请号：EP18724073.4

申请日：2018-04-25

申请人： Ischemix LLC

发明人： BAGUISI, Alexander ,  BEEUWKES, Reinier ,  CASALE, Ralph ,  DEWAHL, David, A. Jr. ,  KATES, Steven, A. ,  LADER, Alan, S.

IPC分类号： A61K31/385 ,  A61K31/4178 ,  A61K31/661 ,  A61K31/662 ,  A61K45/06 ,  A61K38/06 ,  A61K9/00 ,  A61P25/00 ,  A61P25/28 ,  A61P43/00

公开(公告)号：EP2429519A1

公开(公告)日：2012-03-21

申请号：EP10720092.5

申请日：2010-05-13

申请人： Ischemix LLC

发明人： BAGUISI, Alexander, B. ,  BEEUWKES, Reinier ,  CASALE, Ralph ,  KATES, Steven, A. ,  LADER, Alan, S.

IPC分类号： A61K31/385 ,  A61P9/10

CPC分类号： C07K5/06104 ,  A61K31/381 ,  A61K31/385 ,  A61K38/00 ,  A61K38/05 ,  A61K47/64

摘要： The present invention relates, in some embodiments, to compositions comprising a substantially pure compound represented by Structural Formula (I) and methods of using such compounds to activate cytoprotective kinases. In additional embodiments, the invention relates to methods for treating an ischemia or an ischemia-reperfusion injury in a subject, comprising administering to the subject an effective amount of a compound of the invention (e.g., in multiple doses). The values and preferred values of the variables in Structural Formula (I) are defined herein.

公开(公告)号：EP2429519B1

公开(公告)日：2014-04-23

申请号：EP10720092.5

申请日：2010-05-13

申请人： Ischemix LLC

发明人： BAGUISI, Alexander, B. ,  BEEUWKES, Reinier ,  CASALE, Ralph ,  KATES, Steven, A. ,  LADER, Alan, S.

IPC分类号： A61K31/385 ,  A61P9/10

CPC分类号： C07K5/06104 ,  A61K31/381 ,  A61K31/385 ,  A61K38/00 ,  A61K38/05 ,  A61K47/64

公开(公告)号：EP2640423A1

公开(公告)日：2013-09-25

申请号：EP11793558.5

申请日：2011-11-10

申请人： Ischemix LLC

发明人： BAGUISI, Alexander, B. ,  BEEUWKES, Reinier ,  CASALE, Ralph ,  KATES, Steven, A. ,  LADER, Alan, S.

IPC分类号： A61K47/48 ,  C07K5/06 ,  C07D339/04

CPC分类号： C07D339/04 ,  A61K47/64 ,  C07F9/655345 ,  C07K5/06026 ,  C07K5/06078 ,  C07K5/06104 ,  C07K5/06113

摘要： The present invention relates, in various embodiments, to a compound represented by Structural Formula (I), pharmaceutically acceptable salts or prodrugs thereof, and compositions comprising said compounds, or pharmaceutically acceptable salts or prodrugs thereof. Methods of using compounds of Structural Formulas (I) and (la) or compositions comprising compounds of Structural Formulas (I) and (la), or pharmaceutically acceptable salts or prodrugs thereof, to treat ischemia or ischemia-reperfusion injury are also disclosed.

摘要翻译： 本发明在各种实施方案中涉及由结构式（I）表示的化合物，其药学上可接受的盐或前药，以及包含所述化合物或其药学上可接受的盐或前药的组合物。 还公开了使用结构式（I）和（Ia）化合物或包含结构式（I）和（Ia）化合物或其药学上可接受的盐或前药的组合物治疗缺血或缺血再灌注损伤的方法。