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公开(公告)号：EP2971142A1
公开(公告)日：2016-01-20
申请号：EP14767904.7
申请日：2014-03-14
发明人： RIGO, Frank , BENNETT, C., Frank
IPC分类号： C12Q1/68
摘要： Disclosed are methods for modulating splicing of Tau mRNA in an animal with Tau antisense compounds. Also disclosed herein are methods for reducing expression of Tau mRNA and protein in an animal with Tau antisense compounds. Such compounds and methods are useful to treat, prevent, or ameliorate neurodegenerative diseases in an individual in need thereof. Examples of neurodegenerative diseases that can be treated, prevented, and ameliorated with the administration Tau antisense oligonucleotides include Alzheimer's Disease, Fronto-temporal Dementia (FTD), FTDP-17, Progressive Supranuclear Palsy, Chronic Traumatic Encephalopathy, Epilepsy, and Dravet's Syndrome.
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2.发明公开
公开(公告)号：EP2943225A1
公开(公告)日：2015-11-18
申请号：EP14737605.7
申请日：2014-01-09
发明人： BENNETT, C., Frank , HUNG, Gene , RIGO, Frank
CPC分类号： C12N15/113 , A61B5/04012 , A61B5/0488 , A61K9/0019 , A61K9/0085 , A61K31/185 , A61K31/7088 , A61K35/545 , A61K38/30 , A61K45/06 , A61K47/46 , A61K48/00 , C12N2310/11 , C12N2310/315 , C12N2310/322 , C12N2310/351 , C12Q1/6883 , C12Q2600/156 , G01N33/5091
摘要： Disclosed herein are compounds, compositions and methods for modulating splicing of SMN2 mRNA in a subject. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders, including spinal muscular atrophy.
摘要翻译： 在是这样的化合物，组合物和本发明公开了在受试者中调节SMN2 mRNA的剪接方法。 所以本发明提供了在用于治疗疾病和病症，包括脊髓性肌萎缩的药物中的用途游离缺失盘化合物和组合物的用途。
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公开(公告)号：EP2640853A2
公开(公告)日：2013-09-25
申请号：EP11840796.4
申请日：2011-11-17
CPC分类号： C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/323 , C12N2310/3231 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/321 , C12N2310/3525
摘要： Disclosed herein are antisense compounds and methods for decreasing alpha-synuclein mRNA and protein expression. Also disclosed herein are methods for treating, preventing, and ameliorating neurodegenerative diseases in an individual in need thereof.
摘要翻译： 本文公开了用于减少α-突触核蛋白mRNA和蛋白质表达的反义化合物和方法。 本文还公开了用于治疗，预防和改善有需要的个体中的神经变性疾病的方法。
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公开(公告)号：EP2539356A1
公开(公告)日：2013-01-02
申请号：EP11748173.9
申请日：2011-02-25
发明人： DEAN, Nicholas, M. , FOULKES, J., Gordon , FREIER, Susan, M. , BENNETT, C., Frank , GAARDE, William, A.
CPC分类号： A61K31/7088
摘要： Provided are compounds capable of inhibiting SMAD3 and compositions containing same as well as methods using such compounds for treating fibrosis and scarring.
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6.发明授权OLIGONUCLEOTIDE COMPOSITIONS AND METHODS FOR THE MODULATION OF THE EXPRESSION OF B7 PROTEIN 失效OLIGONUCLEOTIDZUSAMMENSTELLUNG和方法调节蛋白B7表达的
公开(公告)号：EP0957926B1
公开(公告)日：2005-02-16
申请号：EP97953268.6
申请日：1997-12-16
CPC分类号： C12N15/1138 , A61K31/711 , A61K38/00 , C07H21/00 , C12N2310/315 , C12N2310/321 , C12N2310/322 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3515 , C12N2310/3525 , C12N2310/3521
摘要： Compositions and methods for the diagnosis, prevention and treatment of immune states and disorders amenable to treatment through modulation of T cell activation are provided. In accordance with preferred embodiments, oligonucleotides are provided which are specifically hybridizable with nucleic acids encoding B7 proteins.
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公开(公告)号：EP1419169A1
公开(公告)日：2004-05-19
申请号：EP02765912.7
申请日：2002-07-31
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of CoREST. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding CoREST. Methods of using these compounds for modulation of CoREST expression and for treatment of diseases associated with expression of CoREST are provided.
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公开(公告)号：EP1358199A2
公开(公告)日：2003-11-05
申请号：EP01988188.7
申请日：2001-11-26
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SRC-1. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SRC-1. Methods of using these compounds for modulation of SRC-1 expression and for treatment of diseases associated with expression of SRC-1 are provided.
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公开(公告)号：EP1346065A2
公开(公告)日：2003-09-24
申请号：EP01993172.4
申请日：2001-11-26
CPC分类号： C12N15/113 , A61K38/00 , A61K48/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of SRC-2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding SRC-2. Methods of using these compounds for modulation of SRC-2 expression and for treatment of diseases associated with expression of SRC-2 are provided.
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公开(公告)号：EP1224202A1
公开(公告)日：2002-07-24
申请号：EP00984591.8
申请日：2000-10-20
CPC分类号： C12Q1/6883 , A61K48/00 , C07B2200/11 , C07H21/00 , C12N9/1205 , C12N15/1137 , C12N2310/321 , C12N2310/3341 , Y02P20/582
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of Integrin-linked kinase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Integrin-linked kinase. Methods of using these compounds for modulation of Integrin-linked kinase expression and for treatment of diseases associated with expression of Integrin-linked kinase are provided.
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