专利检索 ap:("JAPAN ENERGY CORP") AND inv:"MORITA HIROYUKI" 第 1 页

1.

发明公开
METHOD FOR STABILIZING PEPTIDES AND FREEZE-DRIED MEDICINAL COMPOSITIONS CONTAINING PEPTIDES OBTAINED BY USING THE METHOD 失效
标题翻译：方法用于稳定肽及医药组合物与这些GEFRIERGETROCHNETE

公开(公告)号：EP0998942A4

公开(公告)日：2006-08-16

申请号：EP98900424

申请日：1998-01-19

申请人： JAPAN ENERGY CORP

发明人： FURUYA HIDEYUKI , MORITA HIROYUKI , TAKATSU YUKITAKA , MICHIBUCHI KOSE , TANIGAWA MAKOTO

IPC分类号： A61K9/19 , A61K38/58 , A61K47/12 , A61K47/26 , A61P7/02 , A61K9/14

CPC分类号： A61K9/19 , A61K38/58 , A61K47/12 , A61K47/26 , Y10S514/822 , Y10S514/97 , Y10S530/855

摘要： A method for elevating the stability of peptides containing the sequence -Asp-Gly- or -Asn-Gly- by preventing these sequences from changing into succinimide compounds or beta -transition compounds with the passage of time; and freeze-dried medicinal compositions containing hirudin, having excellent stability, and obtained by using the above method. The method comprises adding an organic acid to the solution of the above peptide to regulate the pH value of the solution to 5 to 6.5 followed by freeze-drying. As the peptide, use may be made of disulfite hirudin, hirudin variants, etc. It is also possible to add sucrose, mannitol, etc., together with the organic acid.