公开(公告)号：EP1457211A4

公开(公告)日：2006-06-14

申请号：EP01274763

申请日：2001-11-20

申请人： JAPAN SCIENCE & TECH AGENCY ,  JP NAT INST INFECTIOUS DISEASE

发明人： HONDA MITSUO ,  MATSUO KAZUHIRO ,  OHSU TAKEAKI ,  MIYAMURA TATSUO ,  MATSUURA YOSHIHARU ,  ISHII KOJI ,  KATO KENZO

IPC分类号： A61K39/00 ,  C07K14/16 ,  C12N7/01 ,  C12N7/08 ,  C12N15/49 ,  C12N15/863 ,  A61K39/285 ,  A61K39/21 ,  C12P21/00

CPC分类号： C12N7/00 ,  A61K39/00 ,  A61K2039/5256 ,  A61K2039/53 ,  C07K14/005 ,  C12N15/86 ,  C12N2710/24043 ,  C12N2740/16122

摘要： The invention provides a recombinant vaccinia virus strain DIs that possesses a polynucleotide encoding a foreign antigenic protein in the non-essential gene region of the chromosome DNA and expresses the antigenic protein; and provides a highly-safe, vaccinia virus vaccine containing the recombinant virus strain DIs as the active ingredient. The invention also provides a method of using the vaccinia virus strain DIs as a vector for protein expression.