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公开(公告)号：EP0585549B2
公开(公告)日：2008-01-09
申请号：EP93109289.4
申请日：1993-06-09
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
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2.发明公开Method for producing ectoprotein of hepatitis C virus 失效Verfahren zur Herstellung des Ectoproteins des Hepatitis-C-Virus。
公开(公告)号：EP0585549A2
公开(公告)日：1994-03-09
申请号：EP93109289.4
申请日：1993-06-09
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
摘要： A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis or C type hepatitis in high specificity and sensitivity.
摘要翻译： 一种细胞外产生丙型肝炎病毒的蛋白质的方法包括以下步骤：培养用含有编码丙型肝炎病毒蛋白质的DNA片段的表达载体转化的转化体，并回收由转化体细胞外产生的丙型肝炎病毒的蛋白质 。 起源于通过该方法制备的E1区域的蛋白质可以用作制备用于预防HCV感染的疫苗的材料。 此外，含有蛋白质的诊断剂可用于HCV抗体的检测或其在血清等中的确认。 换句话说，本发明的蛋白质可以诊断或C型肝炎具有高特异性和敏感性。
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3.发明授权Antigenic peptide for detecting anti-hepatitis C virus antibodies and use thereof 失效用于检测抗丙型肝炎病毒抗体的方法及其用途的抗原肽
公开(公告)号：EP0471356B1
公开(公告)日：1997-06-18
申请号：EP91113643.0
申请日：1991-08-14
申请人： JAPAN as represented by Director General of Agency of NATIONAL INSTITUTE OF HEALTH , Chiba, Joe
IPC分类号： C07K7/08 , G01N33/576 , A61K39/29
CPC分类号： C07K14/005 , C12N2770/24222 , Y10S436/82
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公开(公告)号：EP0585549A3
公开(公告)日：1994-07-06
申请号：EP93109289.4
申请日：1993-06-09
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
摘要： A method for extracellularly producing an ectoprotein of hepatitis C virus comprises the steps of cultivating a transformant which is transformed with an expression vector containing a DNA fragment coding for the ectoprotein of hepatitis C virus and recovering the ectoprotein of hepatitis C virus extracellularly produced by the transformant. The protein originated from the E1 region prepared by the method can be used as a material for preparing a vaccine for preventing HCV infection. In addition, a diagnostic agent containing the protein is useful for the detection of an HCV antibody or the confirmation of the presence thereof in sera or the like. In other words, the protein of the present invention permits the diagnosis or C type hepatitis in high specificity and sensitivity.
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5.发明公开Antigenic peptide for detecting anti-hepatitis C virus antibodies and use thereof 失效Antigenes Peptid zum Nachweis von Anti-Hepatitis-C-Virus-Antikörpernund dessen Verwendung。
公开(公告)号：EP0471356A1
公开(公告)日：1992-02-19
申请号：EP91113643.0
申请日：1991-08-14
申请人： JAPAN as represented by Director General of Agency of NATIONAL INSTITUTE OF HEALTH , Chiba, Joe
IPC分类号： C07K7/08 , G01N33/576 , A61K39/29
CPC分类号： C07K14/005 , C12N2770/24222 , Y10S436/82
摘要： The antigenic peptide represented by the following amino acid sequence;
and a method of the detection of anti-HCV antibodies wherein the above peptide is brought into contact with a sample under the conditions that the peptide is bound to anti-HCV antibodies present in the sample to form an immunological complex and the formation of the immunological complex is measured to confirm the existence of the anti-HCV antibodies in the sample. The method is highly specific and sensitive to anti-HCV antibodies.摘要翻译： 由以下氨基酸序列表示的抗原肽; ＆lt; IMAGE＆gt;和检测抗HCV抗体的方法，其中在肽与存在于样品中的抗HCV抗体结合形成免疫复合物和形成的条件下使上述肽与样品接触 测量免疫复合物以确认样品中抗HCV抗体的存在。 该方法对抗HCV抗体具有高度的特异性和敏感性。
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公开(公告)号：EP0585549B1
公开(公告)日：2001-05-23
申请号：EP93109289.4
申请日：1993-06-09
CPC分类号： C07K14/005 , A61K39/00 , C12N2770/24222 , C12N2770/36122
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公开(公告)号：EP0537626B1
公开(公告)日：2001-03-07
申请号：EP92117191.4
申请日：1992-10-08
IPC分类号： G01N33/576 , C07K14/18
CPC分类号： C07K14/005 , C12N2770/24222 , G01N33/5767 , Y10S436/82
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公开(公告)号：EP0537626A1
公开(公告)日：1993-04-21
申请号：EP92117191.4
申请日：1992-10-08
IPC分类号： G01N33/576 , C07K15/00
CPC分类号： C07K14/005 , C12N2770/24222 , G01N33/5767 , Y10S436/82
摘要： A diagnostic reagent for hepatitis C, which detects an antibody induced by infection of hepatitis C virus, characterized in that said diagnostic reagent comprises the second envelope protein or the first non-structural protein which is encoded by the gene of hepatitis C virus and has a suger chain. This invention also provide a method for detecting an anti-hepatitis C virus antibody. The use of the diagnostic reagent for hepatitis C according to the present invention makes highly sensitive diagnosis of hepatitis C possible.
摘要翻译： 一种丙型肝炎诊断试剂，其检测由丙型肝炎病毒感染引起的抗体，其特征在于，所述诊断试剂包含由丙型肝炎病毒基因编码的第二包膜蛋白或第一非结构蛋白， suger链。 本发明还提供了检测抗丙型肝炎病毒抗体的方法。 根据本发明的丙型肝炎诊断试剂的使用使得丙型肝炎的高度敏感性诊断成为可能。
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