公开(公告)号：EP0694038A1

公开(公告)日：1996-01-31

申请号：EP94910353.0

申请日：1994-03-18

申请人： JENAPHARM GmbH

发明人： OETTEL, Michael ,  DROESCHER, Peter ,  SCHWARZ, Sigfrid ,  MENZENBACH, Bernd ,  RÖMER, Wolfgang ,  SCHRÖDER, Jens ,  KAUFMANN, Günther ,  HESCH, Rolf-Dieter

IPC分类号： A61K31 ,  A61P9 ,  A61P35 ,  C07J1 ,  C07J31 ,  C07J41 ,  C07J43

CPC分类号： C07J41/0077 ,  C07J1/0025 ,  C07J31/006 ,  C07J41/0038 ,  C07J41/0088 ,  C07J43/003

摘要： Androgens and their derivates and analogs, such as anabolic agents, are characterized by at least one substituent or substituent grouping with radical trapping properties. These compounds are used as androgen or anabolic agent substitutes or therapeutical agents for treating androgen defficiency; for treating benign prostate hypertrophy and prostate carcinome, in particular with a testosterone-based compound; for treating osteoporosis, in particular post-menopausal osteoporosis in women, preferably associated with estrogen and/or gestagens; for treating brain oedema induced by vasculary or ischemic troubles, subarachnoidal bleeding, ischemic shock and cerebral insult; for treating asthma in its various forms, for treating Alzheimer's disease, Parkinson's disease; for organ transplants; and for treating androgen-dependent and non androgen-dependent malign neoplasia.

公开(公告)号：EP0728140A1

公开(公告)日：1996-08-28

申请号：EP95900069.0

申请日：1994-11-08

申请人： JENAPHARM GmbH

发明人： DROESCHER, Peter ,  MENZENBACH, Bernd ,  PONSOLD, Kurt ,  UNDEUTSCH, Bernd ,  OETTEL, Michael ,  RÖMER, Wolfgang ,  KAUFMANN, Günter ,  SCHRÖDER, Jens

IPC分类号： A61K31 ,  A61P29 ,  C07J1 ,  C07J31 ,  C07J41 ,  C07J51

CPC分类号： C07J1/007 ,  C07J1/0022 ,  C07J1/0088 ,  C07J31/006 ,  C07J41/0044 ,  C07J41/0072 ,  C07J51/00

摘要： Steroids are disclosed with radical-attracting aromatic substituents of general formulae (I) and (II). The new steroids with radical-attracting aromatic substituents are suitable active ingredients in pharmaceuticals for use in the prevention or treatment of radical-induced cell lesions.

公开(公告)号：EP0728140B1

公开(公告)日：2001-09-19

申请号：EP95900069.6

申请日：1994-11-08

申请人： Jenapharm GmbH & Co. KG

发明人： DROESCHER, Peter ,  MENZENBACH, Bernd ,  PONSOLD, Kurt ,  UNDEUTSCH, Bernd ,  OETTEL, Michael ,  RÖMER, Wolfgang ,  KAUFMANN, Günter ,  SCHRÖDER, Jens

IPC分类号： C07J31/00 ,  A61K31/56 ,  C07J51/00 ,  C07J1/00 ,  C07J41/00

CPC分类号： C07J1/007 ,  C07J1/0022 ,  C07J1/0088 ,  C07J31/006 ,  C07J41/0044 ,  C07J41/0072 ,  C07J51/00

摘要： Steroids are disclosed with radical-attracting aromatic substituents of general formulae (I) and (II). The new steroids with radical-attracting aromatic substituents are suitable active ingredients in pharmaceuticals for use in the prevention or treatment of radical-induced cell lesions.

公开(公告)号：EP0728004A1

公开(公告)日：1996-08-28

申请号：EP95900068.0

申请日：1994-11-08

申请人： JENAPHARM GmbH

发明人： DROESCHER, Peter ,  MENZENBACH, Bernd ,  PONSOLD, Kurt ,  UNDEUTSCH, Bernd ,  OETTEL, Michael ,  RÖMER, Wolfgang ,  KAUFMANN, Günter ,  SCHRÖDER, Jens

IPC分类号： A61K31 ,  C07J1

CPC分类号： A61K31/565 ,  A61K31/575

摘要： The present invention pertains to new pharmaceutical preparations for prophylaxis and therapy of radical-mediated cell damage, consisting of steroids with phenolic A-ring structure-except the esterogens estradiol, estrone, estrione and their 2-hydroxy derivates as well as the steroids with cyclic substituents or with an amino group at the terminal C atom of the aliphatic C-17 side chain-and of pharmaceutical adjuvants. These preparations are characterized by a high-level inhibiting action against cell and tissue changes, such as lipid peroxidation and the oxidation of low density lipoprotein (LPL) cholesterol, caused by reactive oxygen species (ROS), free oxygen radicals and other forms of radical; these preparations thus prevent irreversible membrane and endothelial damage resulting therefrom. They therefore contribute to improving the prophylaxis and therapy of radical-induced damage such as that caused by oxygen radicals and/or ROS.