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1.发明公开PHARMAZEUTISCHE PRÄPARATE ZUR GEZIELTEN SUBSTITUTION DES ESTROGENMANGELS IM ZENTRALNERVENSYSTEM 有权药物制剂雌激素缺乏的中枢神经系统靶向代换
公开(公告)号：EP1056460A1
公开(公告)日：2000-12-06
申请号：EP99910118.1
申请日：1999-02-10
发明人： PATCHEV, Vladimir, Dr. , OETTEL, Michael, Prof.Dr. , THIEME, Ina , SCHWARZ, Sigfrid, Prof.Dr. , RÖMER, Wolfgang, Prof.Dr.
IPC分类号： A61K31/565 , A61K31/57
CPC分类号： A61K31/565
摘要： Selected steroids are used to produce pharmaceutical preparations for selectively supplementing oestrogen deficiency in the central nervous system (CNS) without influencing other organs or systems. These steroids are characterised in that they have a selective, neurotropic, oestrogen-like transcription effect, unlike the systemically active natural and synthetic oestrogens, including 17a-estradiol. It has been surprisingly discovered that the selected steroids, when used according to the invention, selectively influence the transcription of oestrogen-dependent genes in the central nervous system and cause alterations of the corresponding physiological parameters; have transcription effects specific to the central nervous systems in doses which have no biological effects on the tissues of the reproductive system; have transcription effects specific to the central nervous system at doses at which neither 17b-estradiol nor 17a-estradiol have any effect; and do not influence the transcription of oestrogen-dependent genes in the central nervous system to a greater extent than the secondary 17b-estradiol.
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2.发明授权14,15-ALPHA-METHYLEN-EQUILENINDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL 有权14,15-α-甲基 - equilenin衍生物，其制造方法相同，并且含药物
公开(公告)号：EP1165596B1
公开(公告)日：2002-06-19
申请号：EP00922533.5
申请日：2000-03-22
IPC分类号： C07J53/00 , A61K31/565 , C07J71/00
CPC分类号： C07J71/001 , C07J53/004
摘要： The invention relates to novel equilenine derivatives of general formula (I) and methods for producing the same and medicaments containing said derivatives. The novel compounds are potent antioxidants and are used in the geriatric prophylaxis in men and women.
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3.发明公开14,15-.ALPHA.-METHYLEN-EQUILENINDERIVATE, VERFAHREN ZU DEREN HERSTELLUNG UND DIESE ENTHALTENDE ARZNEIMITTEL 有权14,15基-α-亚甲基equilenin衍生物，其制造方法相同，并且含药物
公开(公告)号：EP1165596A1
公开(公告)日：2002-01-02
申请号：EP00922533.5
申请日：2000-03-22
IPC分类号： C07J53/00 , A61K31/565 , C07J71/00
CPC分类号： C07J71/001 , C07J53/004
摘要： The invention relates to novel equilenine derivatives of general formula (I) and methods for producing the same and medicaments containing said derivatives. The novel compounds are potent antioxidants and are used in the geriatric prophylaxis in men and women.
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4.发明授权SULFAMAT-DERIVATE VON 1,3,5(10)-ESTRATRIEN-DERIVATEN, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN 失效作者-1,3,5（10） - 雌三烯衍生物，METHOD FOR PRODUCING他们和氨基磺酸酯衍生物的药物COMPOSITIONS CONTAINING
公开(公告)号：EP0862577B1
公开(公告)日：1999-04-14
申请号：EP96945140.0
申请日：1996-09-19
发明人： SCHWARZ, Sigfrid , ELGER, Walter , REDDERSEN, Gudrun , SCHNEIDER, Birgitt , THIEME, Ina , RICHTER, Margit
IPC分类号： C07J41/00 , A61K31/565
CPC分类号： C07J41/0072
摘要： The invention relates to novel sulphamate derivatives of 1,3,5(10)-estratriene derivatives of general formula (I) in which the 3-sulphamate group is acylated, sulphonated or amido-sulphonated. Also disclosed are methods of producing these compounds and pharmaceutical compounds containing them. The claimed compounds have estrogen-like properties.
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5.发明公开SULFAMAT-DERIVATE VON 1,3,5(10)-ESTRATRIEN-DERIVATEN, VERFAHREN ZU IHRER HERSTELLUNG UND DIESE VERBINDUNGEN ENTHALTENDE PHARMAZEUTISCHE ZUSAMMENSETZUNGEN 失效作者-1,3,5（10） - 雌三烯衍生物，METHOD FOR PRODUCING他们和氨基磺酸酯衍生物的药物COMPOSITIONS CONTAINING
公开(公告)号：EP0862577A2
公开(公告)日：1998-09-09
申请号：EP96945140.0
申请日：1996-09-19
申请人： JENAPHARM GmbH
发明人： SCHWARZ, Sigfrid , ELGER, Walter , REDDERSEN, Gudrun , SCHNEIDER, Birgitt , THIEME, Ina , RICHTER, Margit
CPC分类号： C07J41/0072
摘要： The invention relates to novel sulphamate derivatives of 1,3,5(10)-estratriene derivatives of general formula (I) in which the 3-sulphamate group is acylated, sulphonated or amido-sulphonated. Also disclosed are methods of producing these compounds and pharmaceutical compounds containing them. The claimed compounds have estrogen-like properties.
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