专利检索 ap:("JOHNSON MATTHEY PUBLIC LIMITED COMPANY") AND inv:"XU, David" 第 1 页

1.

发明公开
PROCESS FOR PREPARING 1,1'- 1,4-PHENYLENEBIS-(METHYLENE)]-BIS-1,4,8,11-TETRAAZACYCLOTETRADECANE 失效
标题翻译：用于生产1,1“ - （1,4-亚苯基二（亚甲基））-1,4,8,11--tetraazacy-

公开(公告)号：EP0817777A1

公开(公告)日：1998-01-14

申请号：EP96906892.0

申请日：1996-03-19

申请人： JOHNSON MATTHEY PUBLIC LIMITED COMPANY

发明人： XU, David , KAPA, Prasad , REPIC, Oljan , BLACKLOCK, Thomas, J.

IPC分类号： C07C233 , C07C303 , C07C311 , C07D257

CPC分类号： C07C233/36 , C07C311/18 , C07D257/02

摘要： An improved process for preparing 1,1'-[1,4-phenylenebis-(methylene)]-bis-1,4,8,11-tetraazacyclotetradecane comprising the selective functionalization of an acyclic tetramine, and subsequent dimerization and hydrolyzation/tosylation to obtain a 1,4-phenylenebis-methylene bridged hexatosyl acyclic precursor in the first step, the cyclization of said precursor to obtain a hexatosyl cyclam dimer in a second step, and the detosylation of said cyclam dimer in a third step followed by basification to obtain the desired 1,1'-[1,4-phenylenebis-(methylene)]-b-1,4,8,11-tetraazacyclotetradecane.