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公开(公告)号：EP1858542A2
公开(公告)日：2007-11-28
申请号：EP06735178.3
申请日：2006-02-16
IPC分类号： A61K38/17
CPC分类号： A61K38/1709 , C12Q1/527 , C12Q1/6883 , C12Q2600/136 , C12Q2600/158 , G01N33/6893 , G01N2800/32
摘要： The present invention provides methods and composition for the treatment and diagnosis of disorders associated with excessive vascular permeability and edema.
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公开(公告)号：EP2259679A1
公开(公告)日：2010-12-15
申请号：EP09706933.0
申请日：2009-01-30
IPC分类号： A01N43/42
CPC分类号： A61K31/4439 , A61K31/341 , A61K31/343 , A61K31/381 , A61K31/40 , A61K31/402 , A61K31/404 , A61K31/415 , A61K31/4192 , A61K31/426 , A61K31/4436
摘要： We have identified classes of kallikrein inhibitors as compounds that are useful in the reduction of vascular permeability (e.g., retinal vascular permeability and cerebral vascular permeability) and astrocyte activation. Diseases and conditions associated with increased vascular permeability include diabetic retinopathy, hemorrhagic stroke, and macular edema. Diseases and conditions associated with astrocyte activation include Alzheimer's disease, multiple sclerosis, Parkinson's disease, amyotrophic lateral sclerosis, Creutzfeldt- Jakob disease, stroke, epilepsy, and brain trauma.
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3.发明公开
公开(公告)号：EP2369930A1
公开(公告)日：2011-10-05
申请号：EP09831065.9
申请日：2009-12-02
IPC分类号： A01N43/42 , A61K31/42 , A61K31/195
CPC分类号： C07K16/40 , A61K31/195 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/415 , A61K31/4192 , A61K31/42 , A61K31/426 , A61K31/4436 , A61K31/4439 , A61K38/005 , A61K38/02 , A61K39/3955 , A61K45/06 , C07D207/34 , C07D231/14 , C07D249/04 , C07D277/56 , C07D307/68 , C07D333/38 , C07D401/06 , C07D409/04
摘要： The present invention relates to methods of reducing blood pressure in a subject by administering a plasma kallikrein inhibitor.
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