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公开(公告)号：EP4284802A1
公开(公告)日：2023-12-06
申请号：EP22746928.5
申请日：2022-01-31
发明人： BACANI, Genesis, M. , CHAI, Wenying , CHUNG, De, Michael , GOLDBERG, Steven, D. , HIRST, Gavin , KAUSHIK, Virendar , MERCADO-MARIN, Eduardo, V. , RAYMOND, Donald , SEIERSTAD, Mark , SMITH, Russel, C. , SUNDBERG, Thomas , TICHENOR, Mark, S. , VENABLE, Jennifer, D. , WEI, Jianmei , XAVIER, Ramnik
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61K31/4162
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公开(公告)号：EP4284801A1
公开(公告)日：2023-12-06
申请号：EP22746927.7
申请日：2022-01-31
发明人： BACANI, Genesis, M. , CHAI, Wenying , CHUNG, De Michael , GOLDBERG, Steven, D. , HIRST, Gavin , KAUSHIK, Virendar , MERCADO-MARIN, Eduardo, V. , RAYMOND, Donald , SEIERSTAD, Mark , SMITH, Russel, C. , SUNDBERG, Thomas , TICHENOR, Mark, S. , VENABLE, Jennifer, D. , WEI, Jianmei , XAVIER, Ramnik , STEFFENS, Helena, C.
IPC分类号： C07D471/04 , A61K31/435 , A61K31/437 , A61K31/4162
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公开(公告)号：EP4351735A2
公开(公告)日：2024-04-17
申请号：EP22820835.1
申请日：2022-06-06
发明人： MAJEWSKI, Nathan , XAVIER, Ramnik , SUNDBERG, Thomas , TIAN, Gaochao , WISNER, Kyunghye, Ahn , BABBE, Holger
CPC分类号： C07K16/18 , C07K2317/3320130101
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4.发明公开
公开(公告)号：EP3937969A1
公开(公告)日：2022-01-19
申请号：EP20718895.4
申请日：2020-03-13
申请人： The Broad Institute, Inc. , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , The General Hospital Corporation
发明人： XAVIER, Ramnik , DING, Jiarui , XU, Heping , REGEV, Aviv
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公开(公告)号：EP4362709A1
公开(公告)日：2024-05-08
申请号：EP22750941.1
申请日：2022-06-28
申请人： The Broad Institute, Inc. , The General Hospital Corporation , Société des Produits Nestlé S.A.
发明人： XAVIER, Ramnik , VLAMAKIS, Hera , VATANEN, Tommi , SAKWINSKA, Olga , SIEGWALD, Léa , DUBOUX, Stéphane , NGOM-BRU, Catherine
IPC分类号： A23L33/135 , A23L33/00
CPC分类号： A23L33/135 , C12R2001/0120210501 , A23V2200/320420130101 , A23L33/40 , C12N1/205 , A23V2400/53320230801
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公开(公告)号：EP3481830A1
公开(公告)日：2019-05-15
申请号：EP17740232.8
申请日：2017-07-05
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： GRAY, Nathanael, S. , LIANG, Yanke , CHOI, Hwan, Geun , SUNDBERG, Thomas , SHAMJI, Alykhan , XAVIER, Ramnik , FISHER, David E. , MUJAHID, Nisma
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P37/00
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公开(公告)号：EP4047001A3
公开(公告)日：2022-11-30
申请号：EP21218204.2
申请日：2017-07-05
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： GRAY, Nathanael S. , LIANG, Yanke , CHOI, Hwan Geun , SUNDBERG, Thomas , SHAMJI, Alykhan , XAVIER, Ramnik , FISHER, David E. , MUJAHID, Nisma
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P37/00
摘要： The present disclosure provides compounds of Formula ( I ), ( II ), and ( III ). The provided compounds are able to bind protein kinases ( e . g ., SIK) and may be useful in modulating ( e.g., inhibiting) the activity of a protein kinase ( e.g., SIK, ( e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease ( e . g ., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
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公开(公告)号：EP3654993A1
公开(公告)日：2020-05-27
申请号：EP18835095.3
申请日：2018-07-17
申请人： The Broad Institute, Inc. , Massachusetts Institute of Technology , The General Hospital Corporation
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公开(公告)号：EP4047001A2
公开(公告)日：2022-08-24
申请号：EP21218204.2
申请日：2017-07-05
申请人： The Broad Institute, Inc. , Dana-Farber Cancer Institute, Inc. , The General Hospital Corporation
发明人： GRAY, Nathanael S. , LIANG, Yanke , CHOI, Hwan Geun , SUNDBERG, Thomas , SHAMJI, Alykhan , XAVIER, Ramnik , FISHER, David E. , MUJAHID, Nisma
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P7/00 , A61P19/00 , A61P21/00 , A61P25/00 , A61P37/00
摘要： The present disclosure provides compounds of Formula ( I ), ( II ), and ( III ). The provided compounds are able to bind protein kinases ( e . g ., SIK) and may be useful in modulating ( e.g., inhibiting) the activity of a protein kinase ( e.g., SIK, ( e.g., SIK1, SIK2, or SIK3)) in a subject or cell. The provided compounds may be useful in treating or preventing a disease ( e . g ., proliferative disease, musculoskeletal disease, genetic disease, hematological disease, neurological disease, painful condition, psychiatric disorder, or metabolic disorder) in a subject in need thereof. Also provided are pharmaceutical compositions, kits, methods, and uses that include or involve a compound described herein.
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公开(公告)号：EP3177295A2
公开(公告)日：2017-06-14
申请号：EP15829427.2
申请日：2015-08-08
申请人： Dana Farber Cancer Institute, Inc. , The Broad Institute, Inc. , The General Hospital Corporation d/b/a Massachusetts General Hospital , President and Fellows of Harvard College
发明人： SHAMJI, Alykhan , SUNDBERG, Thomas , GRAY, Nathanael , XAVIER, Ramnik , SCHREIBER, Stuart L. , CHOI, Hwan Geun , LIANG, Yanke
IPC分类号： A61K31/519 , A61K31/5377 , C07D498/02
CPC分类号： A61K31/519 , A61K31/506 , A61K31/5377 , A61K45/06
摘要： The present disclosure provides methods of treating and/or preventing inflammatory bowel disease (IBD) and graft-versus-host disease (GVHD) using salt-inducible kinase (SIK) inhibitors, such as macrocyclic SIK inhibitors of Formula (I), imidazolyl SIK inhibitors of Formula (II), and urea and carbamate SIK inhibitors of Formula (III -A) (e.g., urea and carbamate SIK inhibitors of Formula (III)).
摘要翻译： 本公开内容提供了使用盐诱导型激酶（SIK）抑制剂例如式（I）的大环SIK抑制剂，咪唑基SIK（例如咪唑基SIK抑制剂）治疗和/或预防炎性肠病（IBD）和移植物抗宿主病（GVHD） 式（II）的抑制剂和式（III-A）的脲和氨基甲酸酯SIK抑制剂（例如式（III）的脲和氨基甲酸酯SIK抑制剂）。
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