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1.发明公开
公开(公告)号：EP2888277A2
公开(公告)日：2015-07-01
申请号：EP13831719.3
申请日：2013-08-20
发明人： HRYHORENKO, Eric , SANKARAN, Banumathi , DECORY, Thomas R. , TUBBS, Theresa , COLT, Linda , VLIEGEN, Maarten , HASPESLAGH, Pieter Rik
CPC分类号： G01N33/9413 , C07K16/44 , C07K2317/33 , C07K2317/56 , C07K2317/565 , G01N33/9406
摘要： Disclosed is an antibody which binds to paliperidone, which can be used to detect paliperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of paliperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone/paliperidone in a single lateral flow assay device.
摘要翻译： 公开了与利培酮结合的抗体，其可以用于检测样品中的利培酮，例如在竞争性免疫测定法中。 该抗体可以用于侧流测定装置，用于帕立培酮的点护理检测，包括在单个侧流测定装置中多次检测阿立哌唑，喹硫平，奥氮平和利培酮/帕培培酮。
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公开(公告)号：EP2888263A1
公开(公告)日：2015-07-01
申请号：EP13753972.2
申请日：2013-08-20
发明人： HASPESLAGH, Pieter Rik , VLIEGEN, Maarten , HRYHORENKO, Eric , DECORY, Thomas R. , SANKARAN, Banumathi
IPC分类号： C07D487/04 , A61K31/519
CPC分类号： C07K16/44 , C07D471/04 , C07D487/04
摘要： The invention relates to compounds of Formula I, wherein R1 and R2 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from risperidone and paliperidone. The invention also relates to conjugates of a risperidone or paliperidone hapten and a protein.
摘要翻译： 本发明涉及式I化合物，其中R1和R2在本说明书中定义，其可用于合成来自利培酮和普利培酮的新缀合物和免疫原。 本发明还涉及利培酮或普利培酮半抗原和蛋白质的缀合物。
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公开(公告)号：EP2888593A2
公开(公告)日：2015-07-01
申请号：EP13831744.1
申请日：2013-08-20
发明人： HRYHORENKO, Eric , SANKARAN, Banumathi , DECORY, Thomas R. , TUBBS, Theresa , COLT, Linda , VLIEGEN, Maarten , HASPESLAGH, Pieter Rik
CPC分类号： G01N33/94 , C07K16/44 , C07K2317/56 , C07K2317/565 , G01N2800/302
摘要： Disclosed is an antibody which binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
摘要翻译： 公开了结合利培酮的抗体，其可用于检测样品中的利培酮，例如在竞争性免疫测定法中。 该抗体可用于侧流测定装置，用于利培酮的护理点检测，包括在单侧流测定装置中多次检测阿立哌唑，喹硫平，奥氮平和利培酮。
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公开(公告)号：EP2888258A1
公开(公告)日：2015-07-01
申请号：EP13753775.9
申请日：2013-08-20
发明人： HASPESLAGH, Pieter Rik , VLIEGEN, Maarten , HRYHORENKO, Eric , DECORY, Thomas R. , SANKARAN, Banumathi
IPC分类号： C07D471/04 , A61K39/385 , A61K47/48 , G01N33/53
CPC分类号： C07K14/77 , A61K39/385 , A61K47/64 , A61K47/643 , A61K47/646 , A61K2039/6031 , A61K2039/6081 , C07D471/04 , C07K14/47
摘要： The invention relates to compounds of Formula I, wherein L1, L2, and L3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from paliperidone. The invention also relates to conjugates of a paliperidone hapten and a protein.
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公开(公告)号：EP3390449A1
公开(公告)日：2018-10-24
申请号：EP16820526.8
申请日：2016-12-15
发明人： SANKARAN, Banumathi , DECORY, Thomas R. , TUBBS, Theresa , COLT, Linda , VLIEGEN, Maarten , HASPESLAGH, Pieter Rik , HRYHORENKO, Eric
CPC分类号： G01N33/94 , C07K16/00 , C07K16/44 , C07K2317/56 , C07K2317/565
摘要： Disclosed is an antibody or a binding fragment thereof that binds to risperidone, which can be used to detect risperidone in a sample such as in a competitive immunoassay method. The antibody or fragment thereof can be used in a lateral flow assay device for point-of-care detection of risperidone, including multiplex detection of aripiprazole, quetiapine, olanzapine, and risperidone in a single lateral flow assay device.
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