公开(公告)号：EP2129668A1

公开(公告)日：2009-12-09

申请号：EP08731504.0

申请日：2008-03-06

申请人： Janssen Pharmaceutica N.V.

发明人： GAUL, Michael ,  KIM, Alexander ,  SEARLE, Lily, Lee ,  PATCH, Raymond ,  RENTZEPERIS, Dionisios ,  XU, Guozhang ,  ZHU, Xizhen

IPC分类号： C07D263/44 ,  C07D277/34 ,  A61P11/00 ,  A61P19/00 ,  A61P3/04 ,  A61P3/10 ,  A61P35/00 ,  A61K31/426 ,  A61K31/421

CPC分类号： C07D277/34 ,  C07D263/44

摘要： The present invention relates to compounds of Formula (I): methods for preparing these compounds, compositions, intermediates and derivatives thereof and for treating a condition including but not limited to ankylosing spondylitis, artherosclerosis, arthritis (such as rheumatoid arthritis, infectious arthritis, childhood arthritis, psoriatic arthritis, reactive arthritis), bone-related diseases (including those related to bone formation), breast cancer (including those unresponsive to anti-estrogen therapy), cardiovascular disorders, cartilage-related disease (such as cartilage injury/loss, cartilage degeneration, and those related to cartilage formation), chondrodysplasia, chondrosarcoma, chronic back injury, chronic bronchitis, chronic inflammatory airway disease, chronic obstructive pulmonary disease, diabetes, disorders of energy homeostasis, gout, pseudogout, lipid disorders, metabolic syndrome, multiple myeloma, obesity, osteoarthritis, osteogenesis imperfecta, osteolytic bone metastasis, osteomalacia, osteoporosis, Paget's disease, periodontal disease, polymyalgia rheumatica, Reiter's syndrome, repetitive stress injury, hyperglycemia, elevated blood glucose level, and insulin resistance.