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1.发明授权PIPERIDINE OR PIPERAZINE SUBSTITUTED TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID MTP INHIBITING COMPOUNDS 有权哌啶或哌嗪取代的四氢萘-1-羧酸化合物MTP INHIBIT
公开(公告)号：EP2076494B1
公开(公告)日：2010-07-28
申请号：EP07821650.4
申请日：2007-10-22
发明人： MEERPOEL, Lieven , LINDERS, Joannes Theodorus Maria , JAROSKOVA, Libuse , VIELLEVOYE, Marcel , BACKX, Leo Jacobus Jozef , BERTHELOT, Didier Jean-Claude , BUSSCHER, Guuske Frederike
IPC分类号： C07D211/58 , C07D241/20 , C07D295/10 , C07D401/12 , C07D401/14 , A61K31/495 , A61K31/445 , A61P3/00
CPC分类号： C07D241/20 , C07D211/58 , C07D295/10 , C07D401/12 , C07D401/14
摘要： The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
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公开(公告)号：EP3558969A1
公开(公告)日：2019-10-30
申请号：EP17851862.7
申请日：2017-12-20
发明人： LU, Tianbao , ALLISON, Brett Douglas , BARBAY, Joseph Kent , CONNOLLY, Peter J. , CUMMINGS, Maxwell David , DIELS, Gaston , EDWARDS, James Patrick , KREUTTER, Kevin D. , PHILIPPAR, Ulrike , SHEN, Fang , THURING, Johannes Wilhelmus John Fitzgerald , WU, Tongfei , BERTHELOT, Didier Jean-Claude
IPC分类号： C07D401/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61K31/4439 , A61K31/444 , A61K31/4725 , A61K31/538 , A61P35/00
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公开(公告)号：EP3810609A1
公开(公告)日：2021-04-28
申请号：EP19756241.6
申请日：2019-06-13
发明人： CONNOLLY, Peter J. , CUMMINGS, Maxwell David , DIELS, Gaston Stanislas Marcella , THURING, Jan Willem , PHILIPPAR, Ulrike , EDWARDS, James Patrick , BERTHELOT, Didier Jean-Claude , WU, Tongfei , LU, Tianbao
IPC分类号： C07D471/04 , A61K31/4439 , A61P35/00
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4.发明公开PIPERIDINE OR PIPERAZINE SUBSTITUTED TETRAHYDRO-NAPHTHALENE-1-CARBOXYLIC ACID MTP INHIBITING COMPOUNDS 有权哌啶或哌嗪取代的四氢萘-1-羧酸化合物MTP INHIBIT
公开(公告)号：EP2076494A1
公开(公告)日：2009-07-08
申请号：EP07821650.4
申请日：2007-10-22
发明人： MEERPOEL, Lieven , LINDERS, Joannes Theodorus Maria , JAROSKOVA, Libuse , VIELLEVOYE, Marcel , BACKX, Leo Jacobus Jozef , BERTHELOT, Didier Jean-Claude , BUSSCHER, Guuske Frederike
IPC分类号： C07D211/58 , C07D241/20 , C07D295/10 , C07D401/12 , C07D401/14 , A61K31/495 , A61K31/445 , A61P3/00
CPC分类号： C07D241/20 , C07D211/58 , C07D295/10 , C07D401/12 , C07D401/14
摘要： The present invention is concerned with novel piperidine or piperazine substituted tetrahydro-naphthalene-1-carboxylic acid derivatives having apoB secretion/MTP inhibiting activity and concomitant lipid lowering activity. The invention further relates to methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of atherosclerosis, pancreatitis, obesity, hypertriglyceridemia, hypercholesterolemia, hyperlipidemia, diabetes and type II diabetes.
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